A new synthetic toll-like receptor 1/2 ligand is an efficient adjuvant for peptide vaccination in a human volunteer

BACKGROUND: We previously showed that the bacterial lipopeptide Pam(3)Cys-Ser-Ser, meanwhile established as a toll-like receptor (TLR) 1/2 ligand, acts as a strong adjuvant for the induction of virus specific CD8(+) T cells in mice, when covalently coupled to a synthetic peptide. CASE PRESENTATION:...

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Detalles Bibliográficos
Autores principales: Rammensee, Hans-Georg, Wiesmüller, Karl-Heinz, Chandran, P. Anoop, Zelba, Henning, Rusch, Elisa, Gouttefangeas, Cécile, Kowalewski, Daniel J., Di Marco, Moreno, Haen, Sebastian P., Walz, Juliane S., Gloria, Yamel Cardona, Bödder, Johanna, Schertel, Jill-Marie, Tunger, Antje, Müller, Luise, Kießler, Maximilian, Wehner, Rebekka, Schmitz, Marc, Jakobi, Meike, Schneiderhan-Marra, Nicole, Klein, Reinhild, Laske, Karoline, Artzner, Kerstin, Backert, Linus, Schuster, Heiko, Schwenck, Johannes, Weber, Alexander N. R., Pichler, Bernd J., Kneilling, Manfred, la Fougère, Christian, Forchhammer, Stephan, Metzler, Gisela, Bauer, Jürgen, Weide, Benjamin, Schippert, Wilfried, Stevanović, Stefan, Löffler, Markus W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858783/
https://www.ncbi.nlm.nih.gov/pubmed/31730025
http://dx.doi.org/10.1186/s40425-019-0796-5

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