Structure of the Fanconi anemia monoubiquitin ligase complex

The Fanconi Anemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress(1,2). Genetic inactivation of this pathway impairs development, prevents blood production and promotes cancer(1,3). The key molecular step in the FA pat...

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Detalles Bibliográficos
Autores principales: Shakeel, Shabih, Rajendra, Eeson, Alcón, Pablo, O’Reilly, Francis, Chorev, Dror S., Maslen, Sarah, Degliesposti, Gianluca, Russo, Christopher J., He, Shaoda, Hill, Chris H., Skehel, J. Mark, Scheres, Sjors H.W., Patel, Ketan J., Rappsilber, Juri, Robinson, Carol V., Passmore, Lori A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858856/
https://www.ncbi.nlm.nih.gov/pubmed/31666700
http://dx.doi.org/10.1038/s41586-019-1703-4

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