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Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

The activation of T cells by the T cell antigen receptor (TCR) results in the formation of signaling protein complexes (signalosomes), the composition of which has not been analyzed at systems-level. Here, we isolated primary CD4(+) T cells from 15 gene-targeted mice each expressing one tagged-form...

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Detalles Bibliográficos
Autores principales:	Voisinne, Guillaume, Kersse, Kristof, Chaoui, Karima, Lu, Liaoxun, Chaix, Julie, Zhang, Lichen, Menoita, Marisa Goncalves, Girard, Laura, Ounoughene, Youcef, Wang, Hui, Burlet-Schiltz, Odile, Luche, Hervé, Fiore, Frédéric, Malissen, Marie, de Peredo, Anne Gonzalez, Liang, Yinming, Roncagalli, Romain, Malissen, Bernard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859066/ https://www.ncbi.nlm.nih.gov/pubmed/31591574 http://dx.doi.org/10.1038/s41590-019-0489-8

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