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A systems view of spliceosomal assembly and branchpoints with iCLIP

Studies of spliceosomal interactions are challenging due to their dynamic nature. Here we employed spliceosome iCLIP, which immunoprecipitates SmB along with snRNPs and auxiliary RNA binding proteins (RBPs), to map spliceosome engagement with pre-mRNAs in human cell lines. This revealed seven peaks...

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Detalles Bibliográficos
Autores principales:	Briese, Michael, Haberman, Nejc, Sibley, Christopher R., Faraway, Rupert, Elser, Andrea S., Chakrabarti, Anob M., Wang, Zhen, König, Julian, Perera, David, Wickramasinghe, Vihandha O., Venkitaraman, Ashok R., Luscombe, Nicholas M., Saieva, Luciano, Pellizzoni, Livio, Smith, Christopher W.J., Curk, Tomaž, Ule, Jernej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859068/ https://www.ncbi.nlm.nih.gov/pubmed/31570875 http://dx.doi.org/10.1038/s41594-019-0300-4

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