Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage response factors

Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand breaks (DSBs) by RNA polymerase II (RNAPII) are necessary for DNA damage response (DDR) foci formation. We demonstrate that induction of DSBs results in the assembly of functional promoters that include a complete RNAPII...

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Detalles Bibliográficos
Autores principales: Pessina, Fabio, Giavazzi, Fabio, Yin, Yandong, Gioia, Ubaldo, Vitelli, Valerio, Galbiati, Alessandro, Barozzi, Sara, Garre, Massimiliano, Oldani, Amanda, Flaus, Andrew, Cerbino, Roberto, Parazzoli, Dario, Rothenberg, Eli, di Fagagna, Fabrizio d’Adda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859070/
https://www.ncbi.nlm.nih.gov/pubmed/31570834
http://dx.doi.org/10.1038/s41556-019-0392-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859070/
https://www.ncbi.nlm.nih.gov/pubmed/31570834
http://dx.doi.org/10.1038/s41556-019-0392-4

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