Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment

Pneumothorax has been reported as a pazopanib-associated adverse event in patients with lung metastases of soft tissue sarcoma (STS). However, pneumothorax triggered by eribulin treatment has never been reported. We herein report two cases of spontaneous pneumothorax in patients with STS treated wit...

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Autores principales: Takada, Kohichi, Murase, Kazuyuki, Nakamura, Hajime, Hayasaka, Naotaka, Arihara, Yohei, Iyama, Satoshi, Ikeda, Hiroshi, Emori, Makoto, Sugita, Shintaro, Nakamura, Katsuyuki, Miyanishi, Koji, Kobune, Masayoshi, Kato, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859383/
https://www.ncbi.nlm.nih.gov/pubmed/31243217
http://dx.doi.org/10.2169/internalmedicine.2790-19
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author Takada, Kohichi
Murase, Kazuyuki
Nakamura, Hajime
Hayasaka, Naotaka
Arihara, Yohei
Iyama, Satoshi
Ikeda, Hiroshi
Emori, Makoto
Sugita, Shintaro
Nakamura, Katsuyuki
Miyanishi, Koji
Kobune, Masayoshi
Kato, Junji
author_facet Takada, Kohichi
Murase, Kazuyuki
Nakamura, Hajime
Hayasaka, Naotaka
Arihara, Yohei
Iyama, Satoshi
Ikeda, Hiroshi
Emori, Makoto
Sugita, Shintaro
Nakamura, Katsuyuki
Miyanishi, Koji
Kobune, Masayoshi
Kato, Junji
author_sort Takada, Kohichi
collection PubMed
description Pneumothorax has been reported as a pazopanib-associated adverse event in patients with lung metastases of soft tissue sarcoma (STS). However, pneumothorax triggered by eribulin treatment has never been reported. We herein report two cases of spontaneous pneumothorax in patients with STS treated with eribulin. Both patients experienced pneumothorax accompanied by sudden dyspnea on day 9 or 10 of eribulin treatment. These two cases suggest that spontaneous pneumothorax may occur as an adverse event of eribulin treatment in such patients. We should therefore be alert for the potential development of pneumothorax during eribulin treatment of patients with STS and lung metastases.
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spelling pubmed-68593832019-11-21 Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment Takada, Kohichi Murase, Kazuyuki Nakamura, Hajime Hayasaka, Naotaka Arihara, Yohei Iyama, Satoshi Ikeda, Hiroshi Emori, Makoto Sugita, Shintaro Nakamura, Katsuyuki Miyanishi, Koji Kobune, Masayoshi Kato, Junji Intern Med Case Report Pneumothorax has been reported as a pazopanib-associated adverse event in patients with lung metastases of soft tissue sarcoma (STS). However, pneumothorax triggered by eribulin treatment has never been reported. We herein report two cases of spontaneous pneumothorax in patients with STS treated with eribulin. Both patients experienced pneumothorax accompanied by sudden dyspnea on day 9 or 10 of eribulin treatment. These two cases suggest that spontaneous pneumothorax may occur as an adverse event of eribulin treatment in such patients. We should therefore be alert for the potential development of pneumothorax during eribulin treatment of patients with STS and lung metastases. The Japanese Society of Internal Medicine 2019-06-27 2019-10-15 /pmc/articles/PMC6859383/ /pubmed/31243217 http://dx.doi.org/10.2169/internalmedicine.2790-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takada, Kohichi
Murase, Kazuyuki
Nakamura, Hajime
Hayasaka, Naotaka
Arihara, Yohei
Iyama, Satoshi
Ikeda, Hiroshi
Emori, Makoto
Sugita, Shintaro
Nakamura, Katsuyuki
Miyanishi, Koji
Kobune, Masayoshi
Kato, Junji
Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment
title Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment
title_full Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment
title_fullStr Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment
title_full_unstemmed Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment
title_short Pneumothorax as an Adverse Event in Patients with Lung Metastasis of Soft Tissue Sarcoma under Eribulin Treatment
title_sort pneumothorax as an adverse event in patients with lung metastasis of soft tissue sarcoma under eribulin treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859383/
https://www.ncbi.nlm.nih.gov/pubmed/31243217
http://dx.doi.org/10.2169/internalmedicine.2790-19
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