Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome

A 72-year-old man was admitted to a general hospital with progressive liver dysfunction, hypokalemia, hyperglycemia, and nodules in the lung and liver and then transferred to our institution on the seventh hospital day. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, and neuron-specif...

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Detalles Bibliográficos
Autores principales: Kamijo, Sonoko, Hasuike, Satoru, Nakamura, Kenichi, Takaishi, Yuuka, Yamada, Yuri, Ozono, Yoshinori, Tsuchimochi, Mai, Sueta, Mitsue, Kusumoto, Kazunori, Iwakiri, Hisayoshi, Akaki, Mayumi, Tanaka, Hiroyuki, Kataoka, Hiroaki, Shimoda, Kazuya, Nagata, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859385/
https://www.ncbi.nlm.nih.gov/pubmed/31243230
http://dx.doi.org/10.2169/internalmedicine.1976-18
Descripción
Sumario:A 72-year-old man was admitted to a general hospital with progressive liver dysfunction, hypokalemia, hyperglycemia, and nodules in the lung and liver and then transferred to our institution on the seventh hospital day. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, and neuron-specific enolase concentrations were extremely high. He developed acute liver failure, his consciousness and general condition deteriorated rapidly, and he died on Day 11. At the postmortem examination, he was found to have extensive metastases from small-cell lung cancer, including advanced hepatic metastases. This is the first reported case of acute liver failure caused by metastases derived from an ACTH-producing pulmonary small-cell carcinoma.

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