Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome

A 72-year-old man was admitted to a general hospital with progressive liver dysfunction, hypokalemia, hyperglycemia, and nodules in the lung and liver and then transferred to our institution on the seventh hospital day. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, and neuron-specif...

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Autores principales: Kamijo, Sonoko, Hasuike, Satoru, Nakamura, Kenichi, Takaishi, Yuuka, Yamada, Yuri, Ozono, Yoshinori, Tsuchimochi, Mai, Sueta, Mitsue, Kusumoto, Kazunori, Iwakiri, Hisayoshi, Akaki, Mayumi, Tanaka, Hiroyuki, Kataoka, Hiroaki, Shimoda, Kazuya, Nagata, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859385/
https://www.ncbi.nlm.nih.gov/pubmed/31243230
http://dx.doi.org/10.2169/internalmedicine.1976-18
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author Kamijo, Sonoko
Hasuike, Satoru
Nakamura, Kenichi
Takaishi, Yuuka
Yamada, Yuri
Ozono, Yoshinori
Tsuchimochi, Mai
Sueta, Mitsue
Kusumoto, Kazunori
Iwakiri, Hisayoshi
Akaki, Mayumi
Tanaka, Hiroyuki
Kataoka, Hiroaki
Shimoda, Kazuya
Nagata, Kenji
author_facet Kamijo, Sonoko
Hasuike, Satoru
Nakamura, Kenichi
Takaishi, Yuuka
Yamada, Yuri
Ozono, Yoshinori
Tsuchimochi, Mai
Sueta, Mitsue
Kusumoto, Kazunori
Iwakiri, Hisayoshi
Akaki, Mayumi
Tanaka, Hiroyuki
Kataoka, Hiroaki
Shimoda, Kazuya
Nagata, Kenji
author_sort Kamijo, Sonoko
collection PubMed
description A 72-year-old man was admitted to a general hospital with progressive liver dysfunction, hypokalemia, hyperglycemia, and nodules in the lung and liver and then transferred to our institution on the seventh hospital day. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, and neuron-specific enolase concentrations were extremely high. He developed acute liver failure, his consciousness and general condition deteriorated rapidly, and he died on Day 11. At the postmortem examination, he was found to have extensive metastases from small-cell lung cancer, including advanced hepatic metastases. This is the first reported case of acute liver failure caused by metastases derived from an ACTH-producing pulmonary small-cell carcinoma.
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spelling pubmed-68593852019-11-21 Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome Kamijo, Sonoko Hasuike, Satoru Nakamura, Kenichi Takaishi, Yuuka Yamada, Yuri Ozono, Yoshinori Tsuchimochi, Mai Sueta, Mitsue Kusumoto, Kazunori Iwakiri, Hisayoshi Akaki, Mayumi Tanaka, Hiroyuki Kataoka, Hiroaki Shimoda, Kazuya Nagata, Kenji Intern Med Case Report A 72-year-old man was admitted to a general hospital with progressive liver dysfunction, hypokalemia, hyperglycemia, and nodules in the lung and liver and then transferred to our institution on the seventh hospital day. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, and neuron-specific enolase concentrations were extremely high. He developed acute liver failure, his consciousness and general condition deteriorated rapidly, and he died on Day 11. At the postmortem examination, he was found to have extensive metastases from small-cell lung cancer, including advanced hepatic metastases. This is the first reported case of acute liver failure caused by metastases derived from an ACTH-producing pulmonary small-cell carcinoma. The Japanese Society of Internal Medicine 2019-06-27 2019-10-15 /pmc/articles/PMC6859385/ /pubmed/31243230 http://dx.doi.org/10.2169/internalmedicine.1976-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kamijo, Sonoko
Hasuike, Satoru
Nakamura, Kenichi
Takaishi, Yuuka
Yamada, Yuri
Ozono, Yoshinori
Tsuchimochi, Mai
Sueta, Mitsue
Kusumoto, Kazunori
Iwakiri, Hisayoshi
Akaki, Mayumi
Tanaka, Hiroyuki
Kataoka, Hiroaki
Shimoda, Kazuya
Nagata, Kenji
Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome
title Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome
title_full Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome
title_fullStr Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome
title_full_unstemmed Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome
title_short Acute Liver Failure Due to Severe Hepatic Metastasis of Small-cell Lung Cancer Producing Adrenocorticotropic Hormone Complicating Ectopic Cushing Syndrome
title_sort acute liver failure due to severe hepatic metastasis of small-cell lung cancer producing adrenocorticotropic hormone complicating ectopic cushing syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859385/
https://www.ncbi.nlm.nih.gov/pubmed/31243230
http://dx.doi.org/10.2169/internalmedicine.1976-18
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