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HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy
A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859386/ https://www.ncbi.nlm.nih.gov/pubmed/31243235 http://dx.doi.org/10.2169/internalmedicine.2439-18 |
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author | Kawakita, Chieko Kinomura, Masaru Otaka, Nozomu Kitagawa, Masashi Sugiyama, Hitoshi Kusano, Nobuchika Mizuno, Masashi Wada, Jun |
author_facet | Kawakita, Chieko Kinomura, Masaru Otaka, Nozomu Kitagawa, Masashi Sugiyama, Hitoshi Kusano, Nobuchika Mizuno, Masashi Wada, Jun |
author_sort | Kawakita, Chieko |
collection | PubMed |
description | A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated. |
format | Online Article Text |
id | pubmed-6859386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-68593862019-11-21 HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy Kawakita, Chieko Kinomura, Masaru Otaka, Nozomu Kitagawa, Masashi Sugiyama, Hitoshi Kusano, Nobuchika Mizuno, Masashi Wada, Jun Intern Med Case Report A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated. The Japanese Society of Internal Medicine 2019-06-27 2019-10-15 /pmc/articles/PMC6859386/ /pubmed/31243235 http://dx.doi.org/10.2169/internalmedicine.2439-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Kawakita, Chieko Kinomura, Masaru Otaka, Nozomu Kitagawa, Masashi Sugiyama, Hitoshi Kusano, Nobuchika Mizuno, Masashi Wada, Jun HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy |
title | HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy |
title_full | HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy |
title_fullStr | HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy |
title_full_unstemmed | HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy |
title_short | HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy |
title_sort | hiv-associated immune complex kidney disease with c3-dominant deposition induced by hiv infection after treatment of iga nephropathy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859386/ https://www.ncbi.nlm.nih.gov/pubmed/31243235 http://dx.doi.org/10.2169/internalmedicine.2439-18 |
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