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HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy

A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial...

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Autores principales: Kawakita, Chieko, Kinomura, Masaru, Otaka, Nozomu, Kitagawa, Masashi, Sugiyama, Hitoshi, Kusano, Nobuchika, Mizuno, Masashi, Wada, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859386/
https://www.ncbi.nlm.nih.gov/pubmed/31243235
http://dx.doi.org/10.2169/internalmedicine.2439-18
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author Kawakita, Chieko
Kinomura, Masaru
Otaka, Nozomu
Kitagawa, Masashi
Sugiyama, Hitoshi
Kusano, Nobuchika
Mizuno, Masashi
Wada, Jun
author_facet Kawakita, Chieko
Kinomura, Masaru
Otaka, Nozomu
Kitagawa, Masashi
Sugiyama, Hitoshi
Kusano, Nobuchika
Mizuno, Masashi
Wada, Jun
author_sort Kawakita, Chieko
collection PubMed
description A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated.
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spelling pubmed-68593862019-11-21 HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy Kawakita, Chieko Kinomura, Masaru Otaka, Nozomu Kitagawa, Masashi Sugiyama, Hitoshi Kusano, Nobuchika Mizuno, Masashi Wada, Jun Intern Med Case Report A 57-year-old man was diagnosed with IgA nephropathy. Hematuria and proteinuria were improved by tonsillectomy plus methylprednisolone pulse therapy. Lymphadenopathy, hypocomplementemia and pancytopenia were observed six years later, and urinalysis abnormalities recurred. A biopsy revealed mesangial proliferative glomerulonephritis with C3-dominant deposition. Human immunodeficiency virus (HIV) antibody demonstrated positive conversion. He was diagnosed with HIV-associated immune complex kidney disease (HIVICK). The hematuria, proteinuria and hypocomplementemia were improved by reducing the HIV viral load through antiretroviral therapy. When C3-dominant deposition is observed on a renal biopsy, HIVICK must be differentiated. The Japanese Society of Internal Medicine 2019-06-27 2019-10-15 /pmc/articles/PMC6859386/ /pubmed/31243235 http://dx.doi.org/10.2169/internalmedicine.2439-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kawakita, Chieko
Kinomura, Masaru
Otaka, Nozomu
Kitagawa, Masashi
Sugiyama, Hitoshi
Kusano, Nobuchika
Mizuno, Masashi
Wada, Jun
HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy
title HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy
title_full HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy
title_fullStr HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy
title_full_unstemmed HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy
title_short HIV-associated Immune Complex Kidney Disease with C3-dominant Deposition Induced by HIV Infection after Treatment of IgA Nephropathy
title_sort hiv-associated immune complex kidney disease with c3-dominant deposition induced by hiv infection after treatment of iga nephropathy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859386/
https://www.ncbi.nlm.nih.gov/pubmed/31243235
http://dx.doi.org/10.2169/internalmedicine.2439-18
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