Acute Liver Failure Caused by the Transmission of Hepatitis B Virus from the Spouse after 38 Years of Marriage

A 65-year-old man presented with acute liver failure and grade IV coma caused by hepatitis B virus (HBV) infection in 2017. The patient died on day 12 from the disease onset. The HBV isolated from the patient was genotype/subgenotype B/B1 and had multiple genomic mutations. The patient's wife w...

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Detalles Bibliográficos
Autores principales: Sato, Naoto, Watanabe, Shunji, Miura, Kouichi, Goka, Rie, Morimoto, Naoki, Takaoka, Yoshinari, Nomoto, Hiroaki, Tsukui, Mamiko, Isoda, Norio, Nagashima, Shigeo, Takahashi, Masaharu, Okamoto, Hiroaki, Yamamoto, Hironori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859391/
https://www.ncbi.nlm.nih.gov/pubmed/31243227
http://dx.doi.org/10.2169/internalmedicine.3028-19
Descripción
Sumario:A 65-year-old man presented with acute liver failure and grade IV coma caused by hepatitis B virus (HBV) infection in 2017. The patient died on day 12 from the disease onset. The HBV isolated from the patient was genotype/subgenotype B/B1 and had multiple genomic mutations. The patient's wife was hepatitis B surface antigen (HBsAg)-positive when she delivered her first daughter in 1979. The HBV isolates of the patient and the wife shared 100% similarity over the entire genome. Because the patient's HBsAg value had been negative one year earlier, we considered the source of HBV transmission to be his wife.

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