Hepatitis B Virus-associated Vasculitis: Multiple Cavitary Masses in the Lung Mimicking Granulomatous Polyangiitis

Hepatitis B virus (HBV) is one of the main causes of polyarteritis nodosa (PAN). We herein report a rare case of HBV-associated vasculitis presenting with multiple pulmonary nodules, mimicking granulomatous polyangiitis (GPA), with no abnormalities of the ear, nose, or kidney. A surgical lung biopsy...

Descripción completa

Detalles Bibliográficos
Autores principales: Nemoto, Masahiro, Nishioka, Kenjin, Fukuoka, Jun, Aoshima, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859398/
https://www.ncbi.nlm.nih.gov/pubmed/31243226
http://dx.doi.org/10.2169/internalmedicine.3012-19
_version_ 1783471111331119104
author Nemoto, Masahiro
Nishioka, Kenjin
Fukuoka, Jun
Aoshima, Masahiro
author_facet Nemoto, Masahiro
Nishioka, Kenjin
Fukuoka, Jun
Aoshima, Masahiro
author_sort Nemoto, Masahiro
collection PubMed
description Hepatitis B virus (HBV) is one of the main causes of polyarteritis nodosa (PAN). We herein report a rare case of HBV-associated vasculitis presenting with multiple pulmonary nodules, mimicking granulomatous polyangiitis (GPA), with no abnormalities of the ear, nose, or kidney. A surgical lung biopsy revealed geographic necrosis surrounded by palisading granuloma and capillaritis. Because the HBV surface antigen was positive with a serum HBV-DNA level of 2.9 log10 copies/mL, we first treated the patient with entecavir and 2 weeks of prednisone 50 mg/day. The pulmonary nodules resolved, and seroconversion was observed after one month.
format Online
Article
Text
id pubmed-6859398
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-68593982019-11-21 Hepatitis B Virus-associated Vasculitis: Multiple Cavitary Masses in the Lung Mimicking Granulomatous Polyangiitis Nemoto, Masahiro Nishioka, Kenjin Fukuoka, Jun Aoshima, Masahiro Intern Med Case Report Hepatitis B virus (HBV) is one of the main causes of polyarteritis nodosa (PAN). We herein report a rare case of HBV-associated vasculitis presenting with multiple pulmonary nodules, mimicking granulomatous polyangiitis (GPA), with no abnormalities of the ear, nose, or kidney. A surgical lung biopsy revealed geographic necrosis surrounded by palisading granuloma and capillaritis. Because the HBV surface antigen was positive with a serum HBV-DNA level of 2.9 log10 copies/mL, we first treated the patient with entecavir and 2 weeks of prednisone 50 mg/day. The pulmonary nodules resolved, and seroconversion was observed after one month. The Japanese Society of Internal Medicine 2019-06-27 2019-10-15 /pmc/articles/PMC6859398/ /pubmed/31243226 http://dx.doi.org/10.2169/internalmedicine.3012-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nemoto, Masahiro
Nishioka, Kenjin
Fukuoka, Jun
Aoshima, Masahiro
Hepatitis B Virus-associated Vasculitis: Multiple Cavitary Masses in the Lung Mimicking Granulomatous Polyangiitis
title Hepatitis B Virus-associated Vasculitis: Multiple Cavitary Masses in the Lung Mimicking Granulomatous Polyangiitis
title_full Hepatitis B Virus-associated Vasculitis: Multiple Cavitary Masses in the Lung Mimicking Granulomatous Polyangiitis
title_fullStr Hepatitis B Virus-associated Vasculitis: Multiple Cavitary Masses in the Lung Mimicking Granulomatous Polyangiitis
title_full_unstemmed Hepatitis B Virus-associated Vasculitis: Multiple Cavitary Masses in the Lung Mimicking Granulomatous Polyangiitis
title_short Hepatitis B Virus-associated Vasculitis: Multiple Cavitary Masses in the Lung Mimicking Granulomatous Polyangiitis
title_sort hepatitis b virus-associated vasculitis: multiple cavitary masses in the lung mimicking granulomatous polyangiitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859398/
https://www.ncbi.nlm.nih.gov/pubmed/31243226
http://dx.doi.org/10.2169/internalmedicine.3012-19
work_keys_str_mv AT nemotomasahiro hepatitisbvirusassociatedvasculitismultiplecavitarymassesinthelungmimickinggranulomatouspolyangiitis
AT nishiokakenjin hepatitisbvirusassociatedvasculitismultiplecavitarymassesinthelungmimickinggranulomatouspolyangiitis
AT fukuokajun hepatitisbvirusassociatedvasculitismultiplecavitarymassesinthelungmimickinggranulomatouspolyangiitis
AT aoshimamasahiro hepatitisbvirusassociatedvasculitismultiplecavitarymassesinthelungmimickinggranulomatouspolyangiitis

Ejemplares similares