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Polyarteritis Nodosa with Marked Eosinophilia, Associated with Severe Gastrointestinal Tract Involvement and Recurrent Venous Thrombosis

A 45-year-old man was admitted with acute abdominal pain and eosinophilia. Abdominal computed tomography revealed thickness of the ascending and transverse colon with decreased contrast enhancement and a small amount of ascites. In an emergency operation, the necrotic colon was resected. Histopathol...

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Autores principales: Oiwa, Hiroshi, Taniguchi, Kohei, Miyoshi, Natsuki, Sasaki, Keiko, Ichimura, Kouichi, Kubota, Tetsushi, Sato, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859400/
https://www.ncbi.nlm.nih.gov/pubmed/31243218
http://dx.doi.org/10.2169/internalmedicine.2802-19
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author Oiwa, Hiroshi
Taniguchi, Kohei
Miyoshi, Natsuki
Sasaki, Keiko
Ichimura, Kouichi
Kubota, Tetsushi
Sato, Daisuke
author_facet Oiwa, Hiroshi
Taniguchi, Kohei
Miyoshi, Natsuki
Sasaki, Keiko
Ichimura, Kouichi
Kubota, Tetsushi
Sato, Daisuke
author_sort Oiwa, Hiroshi
collection PubMed
description A 45-year-old man was admitted with acute abdominal pain and eosinophilia. Abdominal computed tomography revealed thickness of the ascending and transverse colon with decreased contrast enhancement and a small amount of ascites. In an emergency operation, the necrotic colon was resected. Histopathology showed subserous medium-sized arteritis with abundant eosinophil infiltrates and thrombosis in the portal vein branches. He was diagnosed with polyarteritis nodosa (PAN), and immunosuppressive therapy improved his condition. Two years later, the disease recurred with ischemic cutaneous lesions and marked eosinophilia. Our experience suggests that marked eosinophilia in PAN may imply severe organ involvement, including gastrointestinal necrosis, as well as the association of venous thrombosis.
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spelling pubmed-68594002019-11-21 Polyarteritis Nodosa with Marked Eosinophilia, Associated with Severe Gastrointestinal Tract Involvement and Recurrent Venous Thrombosis Oiwa, Hiroshi Taniguchi, Kohei Miyoshi, Natsuki Sasaki, Keiko Ichimura, Kouichi Kubota, Tetsushi Sato, Daisuke Intern Med Case Report A 45-year-old man was admitted with acute abdominal pain and eosinophilia. Abdominal computed tomography revealed thickness of the ascending and transverse colon with decreased contrast enhancement and a small amount of ascites. In an emergency operation, the necrotic colon was resected. Histopathology showed subserous medium-sized arteritis with abundant eosinophil infiltrates and thrombosis in the portal vein branches. He was diagnosed with polyarteritis nodosa (PAN), and immunosuppressive therapy improved his condition. Two years later, the disease recurred with ischemic cutaneous lesions and marked eosinophilia. Our experience suggests that marked eosinophilia in PAN may imply severe organ involvement, including gastrointestinal necrosis, as well as the association of venous thrombosis. The Japanese Society of Internal Medicine 2019-06-27 2019-10-15 /pmc/articles/PMC6859400/ /pubmed/31243218 http://dx.doi.org/10.2169/internalmedicine.2802-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Oiwa, Hiroshi
Taniguchi, Kohei
Miyoshi, Natsuki
Sasaki, Keiko
Ichimura, Kouichi
Kubota, Tetsushi
Sato, Daisuke
Polyarteritis Nodosa with Marked Eosinophilia, Associated with Severe Gastrointestinal Tract Involvement and Recurrent Venous Thrombosis
title Polyarteritis Nodosa with Marked Eosinophilia, Associated with Severe Gastrointestinal Tract Involvement and Recurrent Venous Thrombosis
title_full Polyarteritis Nodosa with Marked Eosinophilia, Associated with Severe Gastrointestinal Tract Involvement and Recurrent Venous Thrombosis
title_fullStr Polyarteritis Nodosa with Marked Eosinophilia, Associated with Severe Gastrointestinal Tract Involvement and Recurrent Venous Thrombosis
title_full_unstemmed Polyarteritis Nodosa with Marked Eosinophilia, Associated with Severe Gastrointestinal Tract Involvement and Recurrent Venous Thrombosis
title_short Polyarteritis Nodosa with Marked Eosinophilia, Associated with Severe Gastrointestinal Tract Involvement and Recurrent Venous Thrombosis
title_sort polyarteritis nodosa with marked eosinophilia, associated with severe gastrointestinal tract involvement and recurrent venous thrombosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859400/
https://www.ncbi.nlm.nih.gov/pubmed/31243218
http://dx.doi.org/10.2169/internalmedicine.2802-19
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