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Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission

Recently, the World Health Organization recognized that efforts to interrupt schistosomiasis transmission through mass drug administration have been ineffective in some regions; one of their new recommended strategies for global schistosomiasis control emphasizes targeting the freshwater snails that...

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Autores principales: Wood, Chelsea L., Sokolow, Susanne H., Jones, Isabel J., Chamberlin, Andrew J., Lafferty, Kevin D., Kuris, Armand M., Jocque, Merlijn, Hopkins, Skylar, Adams, Grant, Buck, Julia C., Lund, Andrea J., Garcia-Vedrenne, Ana E., Fiorenza, Evan, Rohr, Jason R., Allan, Fiona, Webster, Bonnie, Rabone, Muriel, Webster, Joanne P., Bandagny, Lydie, Ndione, Raphaël, Senghor, Simon, Schacht, Anne-Marie, Jouanard, Nicolas, Riveau, Gilles, De Leo, Giulio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859407/
https://www.ncbi.nlm.nih.gov/pubmed/31659025
http://dx.doi.org/10.1073/pnas.1903698116
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author Wood, Chelsea L.
Sokolow, Susanne H.
Jones, Isabel J.
Chamberlin, Andrew J.
Lafferty, Kevin D.
Kuris, Armand M.
Jocque, Merlijn
Hopkins, Skylar
Adams, Grant
Buck, Julia C.
Lund, Andrea J.
Garcia-Vedrenne, Ana E.
Fiorenza, Evan
Rohr, Jason R.
Allan, Fiona
Webster, Bonnie
Rabone, Muriel
Webster, Joanne P.
Bandagny, Lydie
Ndione, Raphaël
Senghor, Simon
Schacht, Anne-Marie
Jouanard, Nicolas
Riveau, Gilles
De Leo, Giulio A.
author_facet Wood, Chelsea L.
Sokolow, Susanne H.
Jones, Isabel J.
Chamberlin, Andrew J.
Lafferty, Kevin D.
Kuris, Armand M.
Jocque, Merlijn
Hopkins, Skylar
Adams, Grant
Buck, Julia C.
Lund, Andrea J.
Garcia-Vedrenne, Ana E.
Fiorenza, Evan
Rohr, Jason R.
Allan, Fiona
Webster, Bonnie
Rabone, Muriel
Webster, Joanne P.
Bandagny, Lydie
Ndione, Raphaël
Senghor, Simon
Schacht, Anne-Marie
Jouanard, Nicolas
Riveau, Gilles
De Leo, Giulio A.
author_sort Wood, Chelsea L.
collection PubMed
description Recently, the World Health Organization recognized that efforts to interrupt schistosomiasis transmission through mass drug administration have been ineffective in some regions; one of their new recommended strategies for global schistosomiasis control emphasizes targeting the freshwater snails that transmit schistosome parasites. We sought to identify robust indicators that would enable precision targeting of these snails. At the site of the world’s largest recorded schistosomiasis epidemic—the Lower Senegal River Basin in Senegal—intensive sampling revealed positive relationships between intermediate host snails (abundance, density, and prevalence) and human urogenital schistosomiasis reinfection (prevalence and intensity in schoolchildren after drug administration). However, we also found that snail distributions were so patchy in space and time that obtaining useful data required effort that exceeds what is feasible in standard monitoring and control campaigns. Instead, we identified several environmental proxies that were more effective than snail variables for predicting human infection: the area covered by suitable snail habitat (i.e., floating, nonemergent vegetation), the percent cover by suitable snail habitat, and size of the water contact area. Unlike snail surveys, which require hundreds of person-hours per site to conduct, habitat coverage and site area can be quickly estimated with drone or satellite imagery. This, in turn, makes possible large-scale, high-resolution estimation of human urogenital schistosomiasis risk to support targeting of both mass drug administration and snail control efforts.
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spelling pubmed-68594072019-11-21 Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission Wood, Chelsea L. Sokolow, Susanne H. Jones, Isabel J. Chamberlin, Andrew J. Lafferty, Kevin D. Kuris, Armand M. Jocque, Merlijn Hopkins, Skylar Adams, Grant Buck, Julia C. Lund, Andrea J. Garcia-Vedrenne, Ana E. Fiorenza, Evan Rohr, Jason R. Allan, Fiona Webster, Bonnie Rabone, Muriel Webster, Joanne P. Bandagny, Lydie Ndione, Raphaël Senghor, Simon Schacht, Anne-Marie Jouanard, Nicolas Riveau, Gilles De Leo, Giulio A. Proc Natl Acad Sci U S A PNAS Plus Recently, the World Health Organization recognized that efforts to interrupt schistosomiasis transmission through mass drug administration have been ineffective in some regions; one of their new recommended strategies for global schistosomiasis control emphasizes targeting the freshwater snails that transmit schistosome parasites. We sought to identify robust indicators that would enable precision targeting of these snails. At the site of the world’s largest recorded schistosomiasis epidemic—the Lower Senegal River Basin in Senegal—intensive sampling revealed positive relationships between intermediate host snails (abundance, density, and prevalence) and human urogenital schistosomiasis reinfection (prevalence and intensity in schoolchildren after drug administration). However, we also found that snail distributions were so patchy in space and time that obtaining useful data required effort that exceeds what is feasible in standard monitoring and control campaigns. Instead, we identified several environmental proxies that were more effective than snail variables for predicting human infection: the area covered by suitable snail habitat (i.e., floating, nonemergent vegetation), the percent cover by suitable snail habitat, and size of the water contact area. Unlike snail surveys, which require hundreds of person-hours per site to conduct, habitat coverage and site area can be quickly estimated with drone or satellite imagery. This, in turn, makes possible large-scale, high-resolution estimation of human urogenital schistosomiasis risk to support targeting of both mass drug administration and snail control efforts. National Academy of Sciences 2019-11-12 2019-10-28 /pmc/articles/PMC6859407/ /pubmed/31659025 http://dx.doi.org/10.1073/pnas.1903698116 Text en Copyright © 2019 the Author(s). Published by PNAS. http://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle PNAS Plus
Wood, Chelsea L.
Sokolow, Susanne H.
Jones, Isabel J.
Chamberlin, Andrew J.
Lafferty, Kevin D.
Kuris, Armand M.
Jocque, Merlijn
Hopkins, Skylar
Adams, Grant
Buck, Julia C.
Lund, Andrea J.
Garcia-Vedrenne, Ana E.
Fiorenza, Evan
Rohr, Jason R.
Allan, Fiona
Webster, Bonnie
Rabone, Muriel
Webster, Joanne P.
Bandagny, Lydie
Ndione, Raphaël
Senghor, Simon
Schacht, Anne-Marie
Jouanard, Nicolas
Riveau, Gilles
De Leo, Giulio A.
Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission
title Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission
title_full Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission
title_fullStr Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission
title_full_unstemmed Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission
title_short Precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission
title_sort precision mapping of snail habitat provides a powerful indicator of human schistosomiasis transmission
topic PNAS Plus
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859407/
https://www.ncbi.nlm.nih.gov/pubmed/31659025
http://dx.doi.org/10.1073/pnas.1903698116
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