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Yet another job for the bacterial ribosome

The ribosome is a sophisticated cellular machine, composed of RNA and protein, which translates the mRNA-encoded genetic information into protein and thus acts at the center of gene expression. Still, the ribosome not only decodes the genetic information, it also coordinates many ribosome-associated...

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Autores principales: Origi, Andrea, Natriashivili, Ana, Knüpffer, Lara, Fehrenbach, Clara, Denks, Kärt, Asti, Rosella, Koch, Hans-Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859421/
https://www.ncbi.nlm.nih.gov/pubmed/31799325
http://dx.doi.org/10.15698/mic2019.11.698
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author Origi, Andrea
Natriashivili, Ana
Knüpffer, Lara
Fehrenbach, Clara
Denks, Kärt
Asti, Rosella
Koch, Hans-Georg
author_facet Origi, Andrea
Natriashivili, Ana
Knüpffer, Lara
Fehrenbach, Clara
Denks, Kärt
Asti, Rosella
Koch, Hans-Georg
author_sort Origi, Andrea
collection PubMed
description The ribosome is a sophisticated cellular machine, composed of RNA and protein, which translates the mRNA-encoded genetic information into protein and thus acts at the center of gene expression. Still, the ribosome not only decodes the genetic information, it also coordinates many ribosome-associated processes like protein folding and targeting. The ribosomal protein uL23 is crucial for this coordination and is located at the ribosomal tunnel exit where it serves as binding platform for targeting factors, chaperones and modifying enzymes. This includes the signal recognition particle (SRP), which facilitates co-translational protein targeting in pro- and eukaryotes, the chaperone Trigger Factor and methionine aminopeptidase, which removes the start methionine in many bacterial proteins. A recent report revealed the intricate interaction of uL23 with yet another essential player in bacteria, the ATPase SecA, which is best known for its role during post-translational secretion of proteins across the bacterial SecYEG translocon.
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spelling pubmed-68594212019-12-03 Yet another job for the bacterial ribosome Origi, Andrea Natriashivili, Ana Knüpffer, Lara Fehrenbach, Clara Denks, Kärt Asti, Rosella Koch, Hans-Georg Microb Cell Microreview The ribosome is a sophisticated cellular machine, composed of RNA and protein, which translates the mRNA-encoded genetic information into protein and thus acts at the center of gene expression. Still, the ribosome not only decodes the genetic information, it also coordinates many ribosome-associated processes like protein folding and targeting. The ribosomal protein uL23 is crucial for this coordination and is located at the ribosomal tunnel exit where it serves as binding platform for targeting factors, chaperones and modifying enzymes. This includes the signal recognition particle (SRP), which facilitates co-translational protein targeting in pro- and eukaryotes, the chaperone Trigger Factor and methionine aminopeptidase, which removes the start methionine in many bacterial proteins. A recent report revealed the intricate interaction of uL23 with yet another essential player in bacteria, the ATPase SecA, which is best known for its role during post-translational secretion of proteins across the bacterial SecYEG translocon. Shared Science Publishers OG 2019-10-17 /pmc/articles/PMC6859421/ /pubmed/31799325 http://dx.doi.org/10.15698/mic2019.11.698 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Microreview
Origi, Andrea
Natriashivili, Ana
Knüpffer, Lara
Fehrenbach, Clara
Denks, Kärt
Asti, Rosella
Koch, Hans-Georg
Yet another job for the bacterial ribosome
title Yet another job for the bacterial ribosome
title_full Yet another job for the bacterial ribosome
title_fullStr Yet another job for the bacterial ribosome
title_full_unstemmed Yet another job for the bacterial ribosome
title_short Yet another job for the bacterial ribosome
title_sort yet another job for the bacterial ribosome
topic Microreview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859421/
https://www.ncbi.nlm.nih.gov/pubmed/31799325
http://dx.doi.org/10.15698/mic2019.11.698
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