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Endocrine therapy in the years following a diagnosis of breast cancer: A proof of concept study using the primary care prescription database linked to cancer registration data

INTRODUCTION: National cancer registration data were linked to the Primary Care Prescription Database (PCPD) in England. The level of endocrine therapy (ET) prescribed in women after a diagnosis of breast cancer was studied. MATERIALS AND METHODS: Cancer registrations for women diagnosed with breast...

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Detalles Bibliográficos
Autores principales: Emanuel, Gabrielle, Henson, Katherine E., Broggio, John, Charman, Jackie, Horgan, Kieran, Dodwell, David, Darby, Sarah C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859491/
https://www.ncbi.nlm.nih.gov/pubmed/31126816
http://dx.doi.org/10.1016/j.canep.2019.04.012
Descripción
Sumario:INTRODUCTION: National cancer registration data were linked to the Primary Care Prescription Database (PCPD) in England. The level of endocrine therapy (ET) prescribed in women after a diagnosis of breast cancer was studied. MATERIALS AND METHODS: Cancer registrations for women diagnosed with breast cancer during 1995–2015, who survived to 31st March 2015, were linked to ET prescriptions issued during April–July 2015. RESULTS: Among 369 277 survivors of breast cancer diagnosed during 1995–2015, 37% were prescribed ET during April–July 2015. Among women whose breast cancer diagnosis was after 31st July 2010, 81% of those recorded with oestrogen receptor positive (ER+ve) disease were prescribed ET compared with only 6% of those with ER-ve disease. Younger women usually received tamoxifen and older women usually received aromatase inhibitors. DISCUSSION: The pattern of ET use observed in these data corresponds to that expected. This provides confidence in the potential of the PCPD for epidemiological research.