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Polymer Modeling Predicts Chromosome Reorganization in Senescence

Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape. Here, we perform polymer simulations, microscopy, and mass spectrometry to dissect the roles played by heterochromatin- and lamina-mediated int...

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Detalles Bibliográficos
Autores principales:	Chiang, Michael, Michieletto, Davide, Brackley, Chris A., Rattanavirotkul, Nattaphong, Mohammed, Hisham, Marenduzzo, Davide, Chandra, Tamir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859504/ https://www.ncbi.nlm.nih.gov/pubmed/31533042 http://dx.doi.org/10.1016/j.celrep.2019.08.045

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