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ROS and the DNA damage response in cancer
Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-containing molecules that can induce DNA damage and affect the DNA damage response (DDR). There is unequivocal pre-clinical and clinical evidence that ROS influence the genotoxic stress caused by chemotherapeutics agen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859528/ https://www.ncbi.nlm.nih.gov/pubmed/30612957 http://dx.doi.org/10.1016/j.redox.2018.101084 |
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author | Srinivas, Upadhyayula Sai Tan, Bryce W.Q. Vellayappan, Balamurugan A. Jeyasekharan, Anand D. |
author_facet | Srinivas, Upadhyayula Sai Tan, Bryce W.Q. Vellayappan, Balamurugan A. Jeyasekharan, Anand D. |
author_sort | Srinivas, Upadhyayula Sai |
collection | PubMed |
description | Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-containing molecules that can induce DNA damage and affect the DNA damage response (DDR). There is unequivocal pre-clinical and clinical evidence that ROS influence the genotoxic stress caused by chemotherapeutics agents and ionizing radiation. Recent studies have provided mechanistic insight into how ROS can also influence the cellular response to DNA damage caused by genotoxic therapy, especially in the context of Double Strand Breaks (DSBs). This has led to the clinical evaluation of agents modulating ROS in combination with genotoxic therapy for cancer, with mixed success so far. These studies point to context dependent outcomes with ROS modulator combinations with Chemotherapy and radiotherapy, indicating a need for additional pre-clinical research in the field. In this review, we discuss the current knowledge on the effect of ROS in the DNA damage response, and its clinical relevance. |
format | Online Article Text |
id | pubmed-6859528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68595282019-11-22 ROS and the DNA damage response in cancer Srinivas, Upadhyayula Sai Tan, Bryce W.Q. Vellayappan, Balamurugan A. Jeyasekharan, Anand D. Redox Biol Article Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-containing molecules that can induce DNA damage and affect the DNA damage response (DDR). There is unequivocal pre-clinical and clinical evidence that ROS influence the genotoxic stress caused by chemotherapeutics agents and ionizing radiation. Recent studies have provided mechanistic insight into how ROS can also influence the cellular response to DNA damage caused by genotoxic therapy, especially in the context of Double Strand Breaks (DSBs). This has led to the clinical evaluation of agents modulating ROS in combination with genotoxic therapy for cancer, with mixed success so far. These studies point to context dependent outcomes with ROS modulator combinations with Chemotherapy and radiotherapy, indicating a need for additional pre-clinical research in the field. In this review, we discuss the current knowledge on the effect of ROS in the DNA damage response, and its clinical relevance. Elsevier 2018-12-21 /pmc/articles/PMC6859528/ /pubmed/30612957 http://dx.doi.org/10.1016/j.redox.2018.101084 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Srinivas, Upadhyayula Sai Tan, Bryce W.Q. Vellayappan, Balamurugan A. Jeyasekharan, Anand D. ROS and the DNA damage response in cancer |
title | ROS and the DNA damage response in cancer |
title_full | ROS and the DNA damage response in cancer |
title_fullStr | ROS and the DNA damage response in cancer |
title_full_unstemmed | ROS and the DNA damage response in cancer |
title_short | ROS and the DNA damage response in cancer |
title_sort | ros and the dna damage response in cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859528/ https://www.ncbi.nlm.nih.gov/pubmed/30612957 http://dx.doi.org/10.1016/j.redox.2018.101084 |
work_keys_str_mv | AT srinivasupadhyayulasai rosandthednadamageresponseincancer AT tanbrycewq rosandthednadamageresponseincancer AT vellayappanbalamurugana rosandthednadamageresponseincancer AT jeyasekharananandd rosandthednadamageresponseincancer |