Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-α dependent PDK-1 signaling pathway

Melanoma is one of the most malignant and aggressive cancers with high cancer-related deaths. However, it is unclear whether Ku80 regulates tumor growth in human melanoma. In this study, we screened a siRNA library targeting 6024 human genes and identified Ku80 as a potential therapeutic target in m...

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Detalles Bibliográficos
Autores principales: Liu, Tianze, Jin, Lizi, Chen, Miao, Zheng, Zongheng, Lu, Wenjing, Fan, Wenhua, Li, Liren, Zheng, Fufu, Zhu, Qiaohua, Qiu, Huijuan, Liu, Jiani, Chen, Manyu, Tian, Chunfang, Hu, Zheng, Zhang, Changlin, Luo, Meihua, Li, Jian, Kang, Tiebang, Yang, Lukun, Li, Yizhuo, Deng, Wuguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859552/
https://www.ncbi.nlm.nih.gov/pubmed/31023624
http://dx.doi.org/10.1016/j.redox.2019.101197

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