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Redox regulation of motile cilia in airway disease
Motile cilia on airway cells are necessary for clearance of mucus-trapped particles out of the lung. Ciliated airway epithelial cells are uniquely exposed to oxidants through trapping of particles, debris and pathogens in mucus and the direct exposure to inhaled oxidant gases. Dynein ATPases, the mo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859573/ https://www.ncbi.nlm.nih.gov/pubmed/30833143 http://dx.doi.org/10.1016/j.redox.2019.101146 |
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author | Price, Michael E. Sisson, Joseph H. |
author_facet | Price, Michael E. Sisson, Joseph H. |
author_sort | Price, Michael E. |
collection | PubMed |
description | Motile cilia on airway cells are necessary for clearance of mucus-trapped particles out of the lung. Ciliated airway epithelial cells are uniquely exposed to oxidants through trapping of particles, debris and pathogens in mucus and the direct exposure to inhaled oxidant gases. Dynein ATPases, the motors driving ciliary motility, are sensitive to the local redox environment within each cilium. Several redox-sensitive cilia-localized proteins modulate dynein activity and include Protein Kinase A, Protein Kinase C, and Protein Phosphatase 1. Moreover, cilia are rich in known redox regulatory proteins and thioredoxin domain-containing proteins that are critical in maintaining a balanced redox environment. Importantly, a nonsense mutation in TXNDC3, which contains a thioredoxin motif, has recently been identified as disease-causing in Primary Ciliary Dyskinesia, a hereditary motile cilia disease resulting in impaired mucociliary clearance. Here we review current understanding of the role(s) oxidant species play in modifying airway ciliary function. We focus on oxidants generated in the airways, cilia redox targets that modulate ciliary beating and imbalances in redox state that impact health and disease. Finally, we review disease models such as smoking, asthma, alcohol drinking, and infections as well as the direct application of oxidants that implicate redox balance as a modulator of cilia motility. |
format | Online Article Text |
id | pubmed-6859573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68595732019-11-22 Redox regulation of motile cilia in airway disease Price, Michael E. Sisson, Joseph H. Redox Biol Pulmonary Motile cilia on airway cells are necessary for clearance of mucus-trapped particles out of the lung. Ciliated airway epithelial cells are uniquely exposed to oxidants through trapping of particles, debris and pathogens in mucus and the direct exposure to inhaled oxidant gases. Dynein ATPases, the motors driving ciliary motility, are sensitive to the local redox environment within each cilium. Several redox-sensitive cilia-localized proteins modulate dynein activity and include Protein Kinase A, Protein Kinase C, and Protein Phosphatase 1. Moreover, cilia are rich in known redox regulatory proteins and thioredoxin domain-containing proteins that are critical in maintaining a balanced redox environment. Importantly, a nonsense mutation in TXNDC3, which contains a thioredoxin motif, has recently been identified as disease-causing in Primary Ciliary Dyskinesia, a hereditary motile cilia disease resulting in impaired mucociliary clearance. Here we review current understanding of the role(s) oxidant species play in modifying airway ciliary function. We focus on oxidants generated in the airways, cilia redox targets that modulate ciliary beating and imbalances in redox state that impact health and disease. Finally, we review disease models such as smoking, asthma, alcohol drinking, and infections as well as the direct application of oxidants that implicate redox balance as a modulator of cilia motility. Elsevier 2019-02-25 /pmc/articles/PMC6859573/ /pubmed/30833143 http://dx.doi.org/10.1016/j.redox.2019.101146 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Pulmonary Price, Michael E. Sisson, Joseph H. Redox regulation of motile cilia in airway disease |
title | Redox regulation of motile cilia in airway disease |
title_full | Redox regulation of motile cilia in airway disease |
title_fullStr | Redox regulation of motile cilia in airway disease |
title_full_unstemmed | Redox regulation of motile cilia in airway disease |
title_short | Redox regulation of motile cilia in airway disease |
title_sort | redox regulation of motile cilia in airway disease |
topic | Pulmonary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859573/ https://www.ncbi.nlm.nih.gov/pubmed/30833143 http://dx.doi.org/10.1016/j.redox.2019.101146 |
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