Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistance

The ability to selectively eradicate oncogene-addicted tumors while reducing systemic toxicity has endeared targeted therapies as a treatment strategy. Nevertheless, development of acquired resistance limits the benefits and durability of such a regime. Here we report evidence of enhanced reliance o...

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Detalles Bibliográficos
Autores principales: Hirpara, Jayshree, Eu, Jie Qing, Tan, Joanna Kia Min, Wong, Andrea L., Clement, Marie-Veronique, Kong, Li Ren, Ohi, Naoto, Tsunoda, Takeshi, Qu, Jianhua, Goh, Boon Cher, Pervaiz, Shazib
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859574/
https://www.ncbi.nlm.nih.gov/pubmed/30642723
http://dx.doi.org/10.1016/j.redox.2018.101076

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