Restoration of aberrant mTOR signaling by intranasal rapamycin reduces oxidative damage: Focus on HNE-modified proteins in a mouse model of down syndrome

Increasing evidences support the notion that the impairment of intracellular degradative machinery is responsible for the accumulation of oxidized/misfolded proteins that ultimately results in the deposition of protein aggregates. These events are key pathological aspects of “protein misfolding dise...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Domenico, Fabio, Tramutola, Antonella, Barone, Eugenio, Lanzillotta, Chiara, Defever, Olivia, Arena, Andrea, Zuliani, Ilaria, Foppoli, Cesira, Iavarone, Federica, Vincenzoni, Federica, Castagnola, Massimo, Butterfield, D. Allan, Perluigi, Marzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Novel targets of lipoxidation and potential therapeutic strategy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859577/
https://www.ncbi.nlm.nih.gov/pubmed/30876754
http://dx.doi.org/10.1016/j.redox.2019.101162

Ejemplares similares

Ejemplares similares