Immunopeptidomics of colorectal cancer organoids reveals a sparse HLA class I neoantigen landscape and no increase in neoantigens with interferon or MEK-inhibitor treatment

BACKGROUND: Patient derived organoids (PDOs) can be established from colorectal cancers (CRCs) as in vitro models to interrogate cancer biology and its clinical relevance. We applied mass spectrometry (MS) immunopeptidomics to investigate neoantigen presentation and whether this can be augmented thr...

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Detalles Bibliográficos
Autores principales: Newey, Alice, Griffiths, Beatrice, Michaux, Justine, Pak, Hui Song, Stevenson, Brian J., Woolston, Andrew, Semiannikova, Maria, Spain, Georgia, Barber, Louise J., Matthews, Nik, Rao, Sheela, Watkins, David, Chau, Ian, Coukos, George, Racle, Julien, Gfeller, David, Starling, Naureen, Cunningham, David, Bassani-Sternberg, Michal, Gerlinger, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859637/
https://www.ncbi.nlm.nih.gov/pubmed/31735170
http://dx.doi.org/10.1186/s40425-019-0769-8

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