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Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: a propensity score-matched study
This study compared the diagnostic efficacy of transrectal ultrasound (TRUS)-guided prostate biopsy (TRBx) and transperineal prostate biopsy (TPBx) in patients with suspected prostate cancer (PCa). We enrolled 2962 men who underwent transrectal (n = 1216) or transperineal (n = 1746) systematic 12-co...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859663/ https://www.ncbi.nlm.nih.gov/pubmed/31006712 http://dx.doi.org/10.4103/aja.aja_16_19 |
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author | Jiang, Chen-Yi Shen, Peng-Fei Wang, Cheng Gui, Hao-Jun Ruan, Yuan Zeng, Hao Xia, Shu-Jie Wei, Qiang Zhao, Fu-Jun |
author_facet | Jiang, Chen-Yi Shen, Peng-Fei Wang, Cheng Gui, Hao-Jun Ruan, Yuan Zeng, Hao Xia, Shu-Jie Wei, Qiang Zhao, Fu-Jun |
author_sort | Jiang, Chen-Yi |
collection | PubMed |
description | This study compared the diagnostic efficacy of transrectal ultrasound (TRUS)-guided prostate biopsy (TRBx) and transperineal prostate biopsy (TPBx) in patients with suspected prostate cancer (PCa). We enrolled 2962 men who underwent transrectal (n = 1216) or transperineal (n = 1746) systematic 12-core prostate biopsy. Clinical data including age, prostate-specific antigen (PSA) level, and prostate volume (PV) were recorded. To minimize confounding, we performed propensity score-matching analysis. We measured and compared PCa detection rates between TRBx and TPBx, which were stratified by clinical characteristics and Gleason scores. The effects of clinical characteristics on PCa detection rate were assessed by logistic regression. For all patients, TPBx detected a higher proportion of clinically significant PCa (P < 0.001). Logistic regression analyses illustrated that PV had a smaller impact on PCa detection rate of TPBx compared with TRBx. Propensity score-matching analysis showed that the detection rates in TRBx were higher than those in TPBx for patients aged ≥ 80 years (80.4% vs 56.5%, P = 0.004) and with PSA level 20.1–100.0 ng ml(−1) (80.8% vs 69.1%, P = 0.040). In conclusion, TPBx was associated with a higher detection rate of clinically significant PCa than TRBx was; however, because of the high detection rate at certain ages and PSA levels, biopsy approaches should be optimized according to patents' clinical characteristics. |
format | Online Article Text |
id | pubmed-6859663 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-68596632019-12-05 Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: a propensity score-matched study Jiang, Chen-Yi Shen, Peng-Fei Wang, Cheng Gui, Hao-Jun Ruan, Yuan Zeng, Hao Xia, Shu-Jie Wei, Qiang Zhao, Fu-Jun Asian J Androl Original Article This study compared the diagnostic efficacy of transrectal ultrasound (TRUS)-guided prostate biopsy (TRBx) and transperineal prostate biopsy (TPBx) in patients with suspected prostate cancer (PCa). We enrolled 2962 men who underwent transrectal (n = 1216) or transperineal (n = 1746) systematic 12-core prostate biopsy. Clinical data including age, prostate-specific antigen (PSA) level, and prostate volume (PV) were recorded. To minimize confounding, we performed propensity score-matching analysis. We measured and compared PCa detection rates between TRBx and TPBx, which were stratified by clinical characteristics and Gleason scores. The effects of clinical characteristics on PCa detection rate were assessed by logistic regression. For all patients, TPBx detected a higher proportion of clinically significant PCa (P < 0.001). Logistic regression analyses illustrated that PV had a smaller impact on PCa detection rate of TPBx compared with TRBx. Propensity score-matching analysis showed that the detection rates in TRBx were higher than those in TPBx for patients aged ≥ 80 years (80.4% vs 56.5%, P = 0.004) and with PSA level 20.1–100.0 ng ml(−1) (80.8% vs 69.1%, P = 0.040). In conclusion, TPBx was associated with a higher detection rate of clinically significant PCa than TRBx was; however, because of the high detection rate at certain ages and PSA levels, biopsy approaches should be optimized according to patents' clinical characteristics. Wolters Kluwer - Medknow 2019-04-19 /pmc/articles/PMC6859663/ /pubmed/31006712 http://dx.doi.org/10.4103/aja.aja_16_19 Text en Copyright: © The Author(s)(2019) http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Jiang, Chen-Yi Shen, Peng-Fei Wang, Cheng Gui, Hao-Jun Ruan, Yuan Zeng, Hao Xia, Shu-Jie Wei, Qiang Zhao, Fu-Jun Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: a propensity score-matched study |
title | Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: a propensity score-matched study |
title_full | Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: a propensity score-matched study |
title_fullStr | Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: a propensity score-matched study |
title_full_unstemmed | Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: a propensity score-matched study |
title_short | Comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: a propensity score-matched study |
title_sort | comparison of diagnostic efficacy between transrectal and transperineal prostate biopsy: a propensity score-matched study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859663/ https://www.ncbi.nlm.nih.gov/pubmed/31006712 http://dx.doi.org/10.4103/aja.aja_16_19 |
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