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Effect of prolactin on penile erection: a cross-sectional study

Although elevated prolactin levels have been shown to inhibit penile erection, the relationship between prolactin and erection of the penile tip or base has not been extensively researched. We therefore investigated the prolactin's effects on erection of the penile tip and base, with a cross-se...

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Autores principales: Xu, Zhi-He, Pan, Dong, Liu, Tong-Yan, Yuan, Ming-Zhen, Zhang, Jian-Ye, Jiang, Shan, Wang, Xue-Sheng, Guan, Yong, Zhao, Sheng-Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859666/
https://www.ncbi.nlm.nih.gov/pubmed/31044754
http://dx.doi.org/10.4103/aja.aja_22_19
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author Xu, Zhi-He
Pan, Dong
Liu, Tong-Yan
Yuan, Ming-Zhen
Zhang, Jian-Ye
Jiang, Shan
Wang, Xue-Sheng
Guan, Yong
Zhao, Sheng-Tian
author_facet Xu, Zhi-He
Pan, Dong
Liu, Tong-Yan
Yuan, Ming-Zhen
Zhang, Jian-Ye
Jiang, Shan
Wang, Xue-Sheng
Guan, Yong
Zhao, Sheng-Tian
author_sort Xu, Zhi-He
collection PubMed
description Although elevated prolactin levels have been shown to inhibit penile erection, the relationship between prolactin and erection of the penile tip or base has not been extensively researched. We therefore investigated the prolactin's effects on erection of the penile tip and base, with a cross-sectional study of 135 patients with erectile dysfunction, based on scores of ≤21 on the International Index of Erectile Function-5. All patients were tested for nocturnal penile tumescence, blood pressure, serum glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, luteinizing hormone, follicle-stimulating hormone, prolactin, estradiol, testosterone, and progesterone. Univariate and multivariate analyses were used to assess the associations between prolactin levels and erection at the penile tip and base. We found no obvious relationship between erection time at penile tip and prolactin levels, but observed a negative correlation between base erection time and prolactin level (hazard ratio: −2.68; 95% confidence interval [CI]: −5.13–−0.22). With increasing prolactin concentration, multivariate analysis showed obvious reduction in base erection time among patients with normal Rigiscan results (hazard ratio: −3.10; 95% CI: −7.96–1.77; P < 0.05). Our data indicate that prolactin inhibits penile erection, particularly at the penile base. In addition, when the effective erection time of the penile base lasts longer than 10 min, prolactin has a more obvious inhibitory effect on penile base erection.
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spelling pubmed-68596662019-12-05 Effect of prolactin on penile erection: a cross-sectional study Xu, Zhi-He Pan, Dong Liu, Tong-Yan Yuan, Ming-Zhen Zhang, Jian-Ye Jiang, Shan Wang, Xue-Sheng Guan, Yong Zhao, Sheng-Tian Asian J Androl Original Article Although elevated prolactin levels have been shown to inhibit penile erection, the relationship between prolactin and erection of the penile tip or base has not been extensively researched. We therefore investigated the prolactin's effects on erection of the penile tip and base, with a cross-sectional study of 135 patients with erectile dysfunction, based on scores of ≤21 on the International Index of Erectile Function-5. All patients were tested for nocturnal penile tumescence, blood pressure, serum glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, luteinizing hormone, follicle-stimulating hormone, prolactin, estradiol, testosterone, and progesterone. Univariate and multivariate analyses were used to assess the associations between prolactin levels and erection at the penile tip and base. We found no obvious relationship between erection time at penile tip and prolactin levels, but observed a negative correlation between base erection time and prolactin level (hazard ratio: −2.68; 95% confidence interval [CI]: −5.13–−0.22). With increasing prolactin concentration, multivariate analysis showed obvious reduction in base erection time among patients with normal Rigiscan results (hazard ratio: −3.10; 95% CI: −7.96–1.77; P < 0.05). Our data indicate that prolactin inhibits penile erection, particularly at the penile base. In addition, when the effective erection time of the penile base lasts longer than 10 min, prolactin has a more obvious inhibitory effect on penile base erection. Wolters Kluwer - Medknow 2019-04-30 /pmc/articles/PMC6859666/ /pubmed/31044754 http://dx.doi.org/10.4103/aja.aja_22_19 Text en Copyright: © The Author(s)(2019) http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Xu, Zhi-He
Pan, Dong
Liu, Tong-Yan
Yuan, Ming-Zhen
Zhang, Jian-Ye
Jiang, Shan
Wang, Xue-Sheng
Guan, Yong
Zhao, Sheng-Tian
Effect of prolactin on penile erection: a cross-sectional study
title Effect of prolactin on penile erection: a cross-sectional study
title_full Effect of prolactin on penile erection: a cross-sectional study
title_fullStr Effect of prolactin on penile erection: a cross-sectional study
title_full_unstemmed Effect of prolactin on penile erection: a cross-sectional study
title_short Effect of prolactin on penile erection: a cross-sectional study
title_sort effect of prolactin on penile erection: a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859666/
https://www.ncbi.nlm.nih.gov/pubmed/31044754
http://dx.doi.org/10.4103/aja.aja_22_19
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