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Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment

Ginsenosides, the key components isolated from ginseng, have been extensively studied in antitumor treatment. Numerous studies have shown that ginsenosides have direct function in tumor cells through the induction of cancer cell apoptosis and the inhibition of cancer cell growth and enhance the anti...

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Autores principales: Zhang, Yanfei, Qiu, Zhidong, Qiu, Ye, Su, Ting, Qu, Peng, Jia, Ailing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859683/
https://www.ncbi.nlm.nih.gov/pubmed/31729239
http://dx.doi.org/10.1177/1534735419886655
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author Zhang, Yanfei
Qiu, Zhidong
Qiu, Ye
Su, Ting
Qu, Peng
Jia, Ailing
author_facet Zhang, Yanfei
Qiu, Zhidong
Qiu, Ye
Su, Ting
Qu, Peng
Jia, Ailing
author_sort Zhang, Yanfei
collection PubMed
description Ginsenosides, the key components isolated from ginseng, have been extensively studied in antitumor treatment. Numerous studies have shown that ginsenosides have direct function in tumor cells through the induction of cancer cell apoptosis and the inhibition of cancer cell growth and enhance the antitumor immunity through the activation of cytotoxic T lymphocytes and natural killer cells. However, little is known about the function of ginsenosides on myeloid immunosuppressive cells including dendritic cells in tumor, tumor-associated macrophages, and myeloid-derived suppressor cells in the tumor microenvironments. Those myeloid immunosuppressive cells play important roles in promoting tumor angiogenesis, invasion, and metastasis. In the review, we summarize the regulatory functions of ginsenosides on myeloid immunosuppressive cells in tumor microenvironment, providing the novel therapeutic methods for clinical cancer treatment.
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spelling pubmed-68596832019-12-03 Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment Zhang, Yanfei Qiu, Zhidong Qiu, Ye Su, Ting Qu, Peng Jia, Ailing Integr Cancer Ther Review Article Ginsenosides, the key components isolated from ginseng, have been extensively studied in antitumor treatment. Numerous studies have shown that ginsenosides have direct function in tumor cells through the induction of cancer cell apoptosis and the inhibition of cancer cell growth and enhance the antitumor immunity through the activation of cytotoxic T lymphocytes and natural killer cells. However, little is known about the function of ginsenosides on myeloid immunosuppressive cells including dendritic cells in tumor, tumor-associated macrophages, and myeloid-derived suppressor cells in the tumor microenvironments. Those myeloid immunosuppressive cells play important roles in promoting tumor angiogenesis, invasion, and metastasis. In the review, we summarize the regulatory functions of ginsenosides on myeloid immunosuppressive cells in tumor microenvironment, providing the novel therapeutic methods for clinical cancer treatment. SAGE Publications 2019-11-15 /pmc/articles/PMC6859683/ /pubmed/31729239 http://dx.doi.org/10.1177/1534735419886655 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review Article
Zhang, Yanfei
Qiu, Zhidong
Qiu, Ye
Su, Ting
Qu, Peng
Jia, Ailing
Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment
title Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment
title_full Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment
title_fullStr Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment
title_full_unstemmed Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment
title_short Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment
title_sort functional regulation of ginsenosides on myeloid immunosuppressive cells in the tumor microenvironment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859683/
https://www.ncbi.nlm.nih.gov/pubmed/31729239
http://dx.doi.org/10.1177/1534735419886655
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