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The Associations Between Cognitive Prognosis and Kynurenines Are Modified by the Apolipoprotein ε4 Allele Variant in Patients With Dementia

BACKGROUND: The apolipoprotein E ε4 gene variant (APOEε4) confers considerable risk for dementia and affects neuroinflammation, brain metabolism, and synaptic function. The kynurenine pathway (KP) gives rise to neuroactive metabolites, which have inflammatory, redox, and excitotoxic effects in the b...

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Detalles Bibliográficos
Autores principales:	Ervik, Arne Olav, Solvang, Stein-Erik Hafstad, Nordrehaug, Jan Erik, Ueland, Per Magne, Midttun, Øivind, Hildre, Audun, McCann, Adrian, Nygård, Ottar, Aarsland, Dag, Giil, Lasse Melvaer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859685/ https://www.ncbi.nlm.nih.gov/pubmed/31798303 http://dx.doi.org/10.1177/1178646919885637

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