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Clinicoepidemiologic Features of Chronic Spontaneous Urticaria in Patients with Elevated Plasma D-Dimer Levels versus those without It: A Case–Control Cross-Sectional Study of 100 Indian Patients

BACKGROUND: Activated coagulation cascade is implicated in urticaria pathogenesis marked by high plasma D-dimer, a marker of fibrinolysis, levels correlating with high urticaria activity score (UAS) and poor therapeutic outcome. METHODS: Quantitative plasma D-dimer levels and coagulation parameters...

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Autores principales: Chauhan, Shailja, Mahajan, Vikram K., Mehta, Karaninder S., Yadav, Rajinder S., Chauhan, Pushpinder S., Bhushan, Satya, Sharma, Vikas, Sharma, Anuj, Wadhwa, Dhaarna, Sharma, Aditi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859760/
https://www.ncbi.nlm.nih.gov/pubmed/32195199
http://dx.doi.org/10.4103/idoj.IDOJ_505_18
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author Chauhan, Shailja
Mahajan, Vikram K.
Mehta, Karaninder S.
Yadav, Rajinder S.
Chauhan, Pushpinder S.
Bhushan, Satya
Sharma, Vikas
Sharma, Anuj
Wadhwa, Dhaarna
Sharma, Aditi
author_facet Chauhan, Shailja
Mahajan, Vikram K.
Mehta, Karaninder S.
Yadav, Rajinder S.
Chauhan, Pushpinder S.
Bhushan, Satya
Sharma, Vikas
Sharma, Anuj
Wadhwa, Dhaarna
Sharma, Aditi
author_sort Chauhan, Shailja
collection PubMed
description BACKGROUND: Activated coagulation cascade is implicated in urticaria pathogenesis marked by high plasma D-dimer, a marker of fibrinolysis, levels correlating with high urticaria activity score (UAS) and poor therapeutic outcome. METHODS: Quantitative plasma D-dimer levels and coagulation parameters in 100 (male:female ratio 1:3) Indian patients with chronic spontaneous urticaria and age- and gender-matched healthy controls were compared. The clinicoepidemiologic features of chronic urticaria were then compared among patients with normal (≤0.2 mg/L) and elevated (≥0.3 mg/L) plasma D-dimer levels. RESULTS: Plasma D-dimer in 23% patients and 4% controls and prothrombin time and activated partial thromboplastin time in 63% and 5% patients, respectively, were significantly higher compared with 58% and 1% of controls, respectively. About 18 of 72 (25%) patients with high UAS of ≥16–42 were compared with 5 of 28 (17.8%) patients with UAS7 of ≤15. Patients with elevated plasma D-dimer levels had significantly more systemic symptoms (86.9% vs. 81.8%) compared with patients with normal plasma D-dimer levels. CONCLUSION: A subset of patients with chronic urticaria have elevated plasma D-dimer levels and exhibit higher UAS7 and systemic symptoms that may influence long-term prognosis and therapeutic choices. Small number of patients, a cross-sectional nature of study, lack of treatment outcome measures, information on self-medication, and unavailability of specific parameters for coagulation pathway activation remain few limitations of this study.
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spelling pubmed-68597602020-03-19 Clinicoepidemiologic Features of Chronic Spontaneous Urticaria in Patients with Elevated Plasma D-Dimer Levels versus those without It: A Case–Control Cross-Sectional Study of 100 Indian Patients Chauhan, Shailja Mahajan, Vikram K. Mehta, Karaninder S. Yadav, Rajinder S. Chauhan, Pushpinder S. Bhushan, Satya Sharma, Vikas Sharma, Anuj Wadhwa, Dhaarna Sharma, Aditi Indian Dermatol Online J Original Article BACKGROUND: Activated coagulation cascade is implicated in urticaria pathogenesis marked by high plasma D-dimer, a marker of fibrinolysis, levels correlating with high urticaria activity score (UAS) and poor therapeutic outcome. METHODS: Quantitative plasma D-dimer levels and coagulation parameters in 100 (male:female ratio 1:3) Indian patients with chronic spontaneous urticaria and age- and gender-matched healthy controls were compared. The clinicoepidemiologic features of chronic urticaria were then compared among patients with normal (≤0.2 mg/L) and elevated (≥0.3 mg/L) plasma D-dimer levels. RESULTS: Plasma D-dimer in 23% patients and 4% controls and prothrombin time and activated partial thromboplastin time in 63% and 5% patients, respectively, were significantly higher compared with 58% and 1% of controls, respectively. About 18 of 72 (25%) patients with high UAS of ≥16–42 were compared with 5 of 28 (17.8%) patients with UAS7 of ≤15. Patients with elevated plasma D-dimer levels had significantly more systemic symptoms (86.9% vs. 81.8%) compared with patients with normal plasma D-dimer levels. CONCLUSION: A subset of patients with chronic urticaria have elevated plasma D-dimer levels and exhibit higher UAS7 and systemic symptoms that may influence long-term prognosis and therapeutic choices. Small number of patients, a cross-sectional nature of study, lack of treatment outcome measures, information on self-medication, and unavailability of specific parameters for coagulation pathway activation remain few limitations of this study. Wolters Kluwer - Medknow 2019-11-01 /pmc/articles/PMC6859760/ /pubmed/32195199 http://dx.doi.org/10.4103/idoj.IDOJ_505_18 Text en Copyright: © 2019 Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Chauhan, Shailja
Mahajan, Vikram K.
Mehta, Karaninder S.
Yadav, Rajinder S.
Chauhan, Pushpinder S.
Bhushan, Satya
Sharma, Vikas
Sharma, Anuj
Wadhwa, Dhaarna
Sharma, Aditi
Clinicoepidemiologic Features of Chronic Spontaneous Urticaria in Patients with Elevated Plasma D-Dimer Levels versus those without It: A Case–Control Cross-Sectional Study of 100 Indian Patients
title Clinicoepidemiologic Features of Chronic Spontaneous Urticaria in Patients with Elevated Plasma D-Dimer Levels versus those without It: A Case–Control Cross-Sectional Study of 100 Indian Patients
title_full Clinicoepidemiologic Features of Chronic Spontaneous Urticaria in Patients with Elevated Plasma D-Dimer Levels versus those without It: A Case–Control Cross-Sectional Study of 100 Indian Patients
title_fullStr Clinicoepidemiologic Features of Chronic Spontaneous Urticaria in Patients with Elevated Plasma D-Dimer Levels versus those without It: A Case–Control Cross-Sectional Study of 100 Indian Patients
title_full_unstemmed Clinicoepidemiologic Features of Chronic Spontaneous Urticaria in Patients with Elevated Plasma D-Dimer Levels versus those without It: A Case–Control Cross-Sectional Study of 100 Indian Patients
title_short Clinicoepidemiologic Features of Chronic Spontaneous Urticaria in Patients with Elevated Plasma D-Dimer Levels versus those without It: A Case–Control Cross-Sectional Study of 100 Indian Patients
title_sort clinicoepidemiologic features of chronic spontaneous urticaria in patients with elevated plasma d-dimer levels versus those without it: a case–control cross-sectional study of 100 indian patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859760/
https://www.ncbi.nlm.nih.gov/pubmed/32195199
http://dx.doi.org/10.4103/idoj.IDOJ_505_18
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