Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer

The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by NTRK genes and have a role in the development and normal functioning of the nervous system. Since the discovery of an oncogenic NTRK gene fusion in colorectal cancer in 1986, over 80 different fusion partner gen...

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Detalles Bibliográficos
Autores principales: Amatu, A, Sartore-Bianchi, A, Bencardino, K, Pizzutilo, E G, Tosi, F, Siena, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859819/
https://www.ncbi.nlm.nih.gov/pubmed/31738427
http://dx.doi.org/10.1093/annonc/mdz383
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author Amatu, A
Sartore-Bianchi, A
Bencardino, K
Pizzutilo, E G
Tosi, F
Siena, S
author_facet Amatu, A
Sartore-Bianchi, A
Bencardino, K
Pizzutilo, E G
Tosi, F
Siena, S
author_sort Amatu, A
collection PubMed
description The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by NTRK genes and have a role in the development and normal functioning of the nervous system. Since the discovery of an oncogenic NTRK gene fusion in colorectal cancer in 1986, over 80 different fusion partner genes have been identified in a wide array of adult and paediatric tumours, providing actionable targets for targeted therapy. This review describes the normal function and physiology of TRK receptors and the biology behind NTRK gene fusions and how they act as oncogenic drivers in cancer. Finally, an overview of the incidence and prevalence of NTRK gene fusions in various types of cancers is discussed.
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spelling pubmed-68598192019-11-21 Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer Amatu, A Sartore-Bianchi, A Bencardino, K Pizzutilo, E G Tosi, F Siena, S Ann Oncol Reviews The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by NTRK genes and have a role in the development and normal functioning of the nervous system. Since the discovery of an oncogenic NTRK gene fusion in colorectal cancer in 1986, over 80 different fusion partner genes have been identified in a wide array of adult and paediatric tumours, providing actionable targets for targeted therapy. This review describes the normal function and physiology of TRK receptors and the biology behind NTRK gene fusions and how they act as oncogenic drivers in cancer. Finally, an overview of the incidence and prevalence of NTRK gene fusions in various types of cancers is discussed. Oxford University Press 2019-11 2019-11-18 /pmc/articles/PMC6859819/ /pubmed/31738427 http://dx.doi.org/10.1093/annonc/mdz383 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society for Medical Oncology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Amatu, A
Sartore-Bianchi, A
Bencardino, K
Pizzutilo, E G
Tosi, F
Siena, S
Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
title Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
title_full Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
title_fullStr Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
title_full_unstemmed Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
title_short Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
title_sort tropomyosin receptor kinase (trk) biology and the role of ntrk gene fusions in cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859819/
https://www.ncbi.nlm.nih.gov/pubmed/31738427
http://dx.doi.org/10.1093/annonc/mdz383
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