Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity

Proteinaceous inclusions containing alpha-synuclein (α-Syn) have been implicated in neuronal toxicity in Parkinson’s disease, but the pathways that modulate toxicity remain enigmatic. Here, we used a targeted proteomic assay to simultaneously measure 269 pathway activation markers and proteins dereg...

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Detalles Bibliográficos
Autores principales: Soste, Martin, Charmpi, Konstantina, Lampert, Fabienne, Gerez, Juan Atilio, van Oostrum, Marc, Malinovska, Liliana, Boersema, Paul Jonathan, Prymaczok, Natalia Cecilia, Riek, Roland, Peter, Matthias, Vanni, Stefano, Beyer, Andreas, Picotti, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859835/
https://www.ncbi.nlm.nih.gov/pubmed/31521608
http://dx.doi.org/10.1016/j.cels.2019.07.010

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