Sox2(+) cells in Sonic Hedgehog-subtype medulloblastoma resist p53-mediated cell-cycle arrest response and drive therapy-induced recurrence

BACKGROUND: High-intensity therapy effectively treats most TP53 wild-type (TP53-WT) Sonic Hedgehog-subgroup medulloblastomas (SHH-MBs), but often cause long-term deleterious neurotoxicities in children. Recent clinical trials investigating reduction/de-escalation of therapy for TP53-WT SHH-MBs cause...

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Detalles Bibliográficos
Autores principales: Treisman, Daniel M, Li, Yinghua, Pierce, Brianna R, Li, Chaoyang, Chervenak, Andrew P, Tomasek, Gerald J, Lozano, Guillermina, Zheng, Xiaoyan, Kool, Marcel, Zhu, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860004/
https://www.ncbi.nlm.nih.gov/pubmed/31763624
http://dx.doi.org/10.1093/noajnl/vdz027

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