Cargando…

Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors

P21-activated kinases (PAKs) are serine/threonine protein kinases that are subdivided into two groups on the basis of their domain architecture: group-I (PAK1–3) and group-II (PAK4–6). PAKs are considered as attractive drug targets that play vital role in cell proliferation, survival, motility, angi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gul, Mehreen, Fakhar, Muhammad, Najumuddin, Rashid, Sajid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860928/ https://www.ncbi.nlm.nih.gov/pubmed/31738805 http://dx.doi.org/10.1371/journal.pone.0225132

Ejemplares similares

SHP-1 tyrosine phosphatase binding to c-Src kinase phosphor-dependent conformations: A comparative structural framework
por: Gul, Mehreen, et al.
Publicado: (2023)

Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer
por: Kenyon, Colin P, et al.
Publicado: (2012)

ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy
por: Olivieri, Cristina, et al.
Publicado: (2022)

Divergent Modulation of Src-Family Kinase Regulatory Interactions with ATP-Competitive Inhibitors
por: Leonard, Stephen E., et al.
Publicado: (2014)

Protein kinase CK2 phosphorylates and activates p21-activated kinase 1
por: Shin, Yong Jae, et al.
Publicado: (2013)

Competition between members of the tribbles pseudokinase protein family shapes their interactions with mitogen activated protein kinase pathways
por: Guan, Hongtao, et al.
Publicado: (2016)

Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2
por: Anderson, Jake W., et al.
Publicado: (2023)

Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands
por: Ferri, Elena, et al.
Publicado: (2020)

The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN
por: Nakano, Shun, et al.
Publicado: (2022)

Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation
por: Gilburt, James A. H., et al.
Publicado: (2019)

RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes
por: Ganju, Ramesh K., et al.
Publicado: (1997)

Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors
por: Bogusz, Jozefina, et al.
Publicado: (2017)

JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21
por: Colleoni, B, et al.
Publicado: (2017)

The Toxoplasma Kinase ROP18: An Active Member of a Degenerate Family
por: Sinai, Anthony P
Publicado: (2007)

The p21-Activated Kinase (PAK) Family Member PakD Is Required for Chemorepulsion and Proliferation Inhibition by Autocrine Signals in Dictyostelium discoideum
por: Phillips, Jonathan E., et al.
Publicado: (2014)

E2(UbcH5B)-derived peptide ligands target HECT E3-E2 binding site and block the Ub-dependent SARS-CoV-2 egression: A computational study
por: Zahid, Sana, et al.
Publicado: (2022)

Exploration of charge states of balanol analogues acting as ATP-competitive inhibitors in kinases
por: Hardianto, Ari, et al.
Publicado: (2017)

p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II
por: Saldivar-Cerón, Héctor I., et al.
Publicado: (2022)

Estrogen induces phosphorylation of prolactin through p21-activated kinase 2 activation in the mouse pituitary gland
por: MOROHOSHI, Kazunori, et al.
Publicado: (2020)

A Series of Isatin-Hydrazones with Cytotoxic Activity and CDK2 Kinase Inhibitory Activity: A Potential Type II ATP Competitive Inhibitor
por: Al-Salem, Huda S., et al.
Publicado: (2020)

Phosphorylation at Ser(26) in the ATP-binding site of Ca(2+)/calmodulin-dependent kinase II as a mechanism for switching off the kinase activity
por: Yilmaz, Mehtap, et al.
Publicado: (2013)

In Silico Analysis Reveals 75 Members of Mitogen-Activated Protein Kinase Kinase Kinase Gene Family in Rice
por: Rao, Kudupudi Prabhakara, et al.
Publicado: (2010)

Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity
por: Aho, Teija LT, et al.
Publicado: (2006)

p21‐activated kinase 4 phosphorylates peroxisome proliferator‐activated receptor Υ and suppresses skeletal muscle regeneration
por: Mao, Yuancheng, et al.
Publicado: (2021)

ATP Competitive Protein Kinase C Inhibitors Demonstrate Distinct State-Dependent Inhibition
por: Smith, Ida M., et al.
Publicado: (2011)

A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties
por: Pitman, Melissa R., et al.
Publicado: (2015)

Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells
por: Blaser, Benjamin, et al.
Publicado: (2012)

Imine Deaminase Activity and Conformational Stability of UK114, the Mammalian Member of the Rid Protein Family Active in Amino Acid Metabolism
por: Degani, Genny, et al.
Publicado: (2018)

Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation
por: Jambrina, Pablo G., et al.
Publicado: (2015)

Conformational coupling by trans-phosphorylation in calcium calmodulin dependent kinase II
por: Pandini, Alessandro, et al.
Publicado: (2019)

The role of the C8 proton of ATP in the regulation of phosphoryl transfer within kinases and synthetases
por: Kenyon, Colin P, et al.
Publicado: (2011)

Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity
por: Ng, Khong Y., et al.
Publicado: (2014)

Recent development of ATP-competitive small molecule phosphatidylinostitol-3-kinase inhibitors as anticancer agents
por: Liu, Yu, et al.
Publicado: (2016)

Examining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors
por: Wong, Margaret L., et al.
Publicado: (2017)

Marine-Derived Natural Products as ATP-Competitive mTOR Kinase Inhibitors for Cancer Therapeutics
por: Parate, Shraddha, et al.
Publicado: (2021)

Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases
por: Mideros-Mora, Cristina, et al.
Publicado: (2020)

Phosphorylation impact on Spleen Tyrosine kinase conformation by Surface Enhanced Raman Spectroscopy
por: Cottat, Maximilien, et al.
Publicado: (2017)

Human members of the eukaryotic protein kinase family
por: Kostich, Mitch, et al.
Publicado: (2002)

Functions of the RIP kinase family members in the skin
por: Urwyler-Rösselet, Corinne, et al.
Publicado: (2023)

Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation
por: Hegedüs, Luca, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6k64esggpisgb258va3posoae8