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Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression

The impact of performing exercise on the immune system presents contrasting effects on health when performed at different intensities. In addition, the consequences of performing chronic exercise have not been sufficiently studied in contrast to the effects of acute bouts of exercise. The porpoise o...

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Autores principales: Valencia-Sánchez, Salvador, Nava-Castro, Karen Elizabeth, Palacios-Arreola, Margarita Isabel, Prospéro-García, Oscar, Morales-Montor, Jorge, Drucker-Colín, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860935/
https://www.ncbi.nlm.nih.gov/pubmed/31738771
http://dx.doi.org/10.1371/journal.pone.0220542
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author Valencia-Sánchez, Salvador
Nava-Castro, Karen Elizabeth
Palacios-Arreola, Margarita Isabel
Prospéro-García, Oscar
Morales-Montor, Jorge
Drucker-Colín, René
author_facet Valencia-Sánchez, Salvador
Nava-Castro, Karen Elizabeth
Palacios-Arreola, Margarita Isabel
Prospéro-García, Oscar
Morales-Montor, Jorge
Drucker-Colín, René
author_sort Valencia-Sánchez, Salvador
collection PubMed
description The impact of performing exercise on the immune system presents contrasting effects on health when performed at different intensities. In addition, the consequences of performing chronic exercise have not been sufficiently studied in contrast to the effects of acute bouts of exercise. The porpoise of this work was to determine the effect that a popular exercise regimen (chronic/moderate/aerobic exercise) has on the proportion of different immune cell subsets, their function and if it affects the cannabinoid system with potentially functional implications on the immune system. A marked increase in several immune cell subsets and their expression of cannabinoid receptors was expected, as well as an enhanced proliferative and cytotoxic activity by total splenocytes in exercised animals. For this study male Wistar rats performed treadmill running 5 times a week for a period of 10 weeks, at moderate intensity. Our results showed a significant decrease in lymphocyte subpopulations (CD4+, Tγδ, and CD45 RA+ cells) and an increase in the cannabinoid receptors expression in those same cell. Although functional assays did not reveal any variation in total immunoglobulin production or NK cells cytotoxic activity, proliferative capability of total splenocytes increased in trained rats. Our results further support the notion that exercise affects the immunological system and extends the description of underlying mechanisms mediating such effects. Altogether, our results contribute to the understanding of the benefits of exercise on the practitioner´s general health.
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spelling pubmed-68609352019-12-07 Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression Valencia-Sánchez, Salvador Nava-Castro, Karen Elizabeth Palacios-Arreola, Margarita Isabel Prospéro-García, Oscar Morales-Montor, Jorge Drucker-Colín, René PLoS One Research Article The impact of performing exercise on the immune system presents contrasting effects on health when performed at different intensities. In addition, the consequences of performing chronic exercise have not been sufficiently studied in contrast to the effects of acute bouts of exercise. The porpoise of this work was to determine the effect that a popular exercise regimen (chronic/moderate/aerobic exercise) has on the proportion of different immune cell subsets, their function and if it affects the cannabinoid system with potentially functional implications on the immune system. A marked increase in several immune cell subsets and their expression of cannabinoid receptors was expected, as well as an enhanced proliferative and cytotoxic activity by total splenocytes in exercised animals. For this study male Wistar rats performed treadmill running 5 times a week for a period of 10 weeks, at moderate intensity. Our results showed a significant decrease in lymphocyte subpopulations (CD4+, Tγδ, and CD45 RA+ cells) and an increase in the cannabinoid receptors expression in those same cell. Although functional assays did not reveal any variation in total immunoglobulin production or NK cells cytotoxic activity, proliferative capability of total splenocytes increased in trained rats. Our results further support the notion that exercise affects the immunological system and extends the description of underlying mechanisms mediating such effects. Altogether, our results contribute to the understanding of the benefits of exercise on the practitioner´s general health. Public Library of Science 2019-11-18 /pmc/articles/PMC6860935/ /pubmed/31738771 http://dx.doi.org/10.1371/journal.pone.0220542 Text en © 2019 Valencia-Sánchez et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Valencia-Sánchez, Salvador
Nava-Castro, Karen Elizabeth
Palacios-Arreola, Margarita Isabel
Prospéro-García, Oscar
Morales-Montor, Jorge
Drucker-Colín, René
Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression
title Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression
title_full Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression
title_fullStr Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression
title_full_unstemmed Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression
title_short Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression
title_sort chronic exercise modulates the cellular immunity and its cannabinoid receptors expression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6860935/
https://www.ncbi.nlm.nih.gov/pubmed/31738771
http://dx.doi.org/10.1371/journal.pone.0220542
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