Pennies for Your Thoughts: A Case Series of Pancytopenia Due to Zinc-induced Copper Deficiency in the Same Patient

A 47-year-old schizophrenic male presented on three separate occasions with pancytopenia and sideroblastic anemia due to copper deficiency from massive zinc penny ingestion. The poisoning was treated differently on each visit: intravenous (IV) copper plus surgical decontamination and chelation with...

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Detalles Bibliográficos
Autores principales: Dolcourt, Bram A., Paxton, James H., Bora, Keenan M., Aaron, Cynthia K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: University of California Irvine, Department of Emergency Medicine publishing Western Journal of Emergency Medicine 2019
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861045/
https://www.ncbi.nlm.nih.gov/pubmed/31763583
http://dx.doi.org/10.5811/cpcem.2019.7.43697
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author Dolcourt, Bram A.
Paxton, James H.
Bora, Keenan M.
Aaron, Cynthia K.
author_facet Dolcourt, Bram A.
Paxton, James H.
Bora, Keenan M.
Aaron, Cynthia K.
author_sort Dolcourt, Bram A.
collection PubMed
description A 47-year-old schizophrenic male presented on three separate occasions with pancytopenia and sideroblastic anemia due to copper deficiency from massive zinc penny ingestion. The poisoning was treated differently on each visit: intravenous (IV) copper plus surgical decontamination and chelation with calcium disodium versenate (CaNa2EDTA); IV copper plus whole bowel irrigation; and IV copper with surgical decontamination only. Serum zinc half-lives were 80.0 hours, 233.2 hours, and 83.9 hours, respectively. Importantly, chelation with CaNa2EDTA did not significantly alter the elimination half-life. This is the first reported case of the same patient being treated on three different occasions with three different regimens for this condition.
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spelling pubmed-68610452019-11-22 Pennies for Your Thoughts: A Case Series of Pancytopenia Due to Zinc-induced Copper Deficiency in the Same Patient Dolcourt, Bram A. Paxton, James H. Bora, Keenan M. Aaron, Cynthia K. Clin Pract Cases Emerg Med Case Series A 47-year-old schizophrenic male presented on three separate occasions with pancytopenia and sideroblastic anemia due to copper deficiency from massive zinc penny ingestion. The poisoning was treated differently on each visit: intravenous (IV) copper plus surgical decontamination and chelation with calcium disodium versenate (CaNa2EDTA); IV copper plus whole bowel irrigation; and IV copper with surgical decontamination only. Serum zinc half-lives were 80.0 hours, 233.2 hours, and 83.9 hours, respectively. Importantly, chelation with CaNa2EDTA did not significantly alter the elimination half-life. This is the first reported case of the same patient being treated on three different occasions with three different regimens for this condition. University of California Irvine, Department of Emergency Medicine publishing Western Journal of Emergency Medicine 2019-10-14 /pmc/articles/PMC6861045/ /pubmed/31763583 http://dx.doi.org/10.5811/cpcem.2019.7.43697 Text en Copyright: © 2019 Dolcourt et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) License. See: http://creativecommons.org/licenses/by/4.0/
spellingShingle Case Series
Dolcourt, Bram A.
Paxton, James H.
Bora, Keenan M.
Aaron, Cynthia K.
Pennies for Your Thoughts: A Case Series of Pancytopenia Due to Zinc-induced Copper Deficiency in the Same Patient
title Pennies for Your Thoughts: A Case Series of Pancytopenia Due to Zinc-induced Copper Deficiency in the Same Patient
title_full Pennies for Your Thoughts: A Case Series of Pancytopenia Due to Zinc-induced Copper Deficiency in the Same Patient
title_fullStr Pennies for Your Thoughts: A Case Series of Pancytopenia Due to Zinc-induced Copper Deficiency in the Same Patient
title_full_unstemmed Pennies for Your Thoughts: A Case Series of Pancytopenia Due to Zinc-induced Copper Deficiency in the Same Patient
title_short Pennies for Your Thoughts: A Case Series of Pancytopenia Due to Zinc-induced Copper Deficiency in the Same Patient
title_sort pennies for your thoughts: a case series of pancytopenia due to zinc-induced copper deficiency in the same patient
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861045/
https://www.ncbi.nlm.nih.gov/pubmed/31763583
http://dx.doi.org/10.5811/cpcem.2019.7.43697
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