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SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases

Neurodegenerative diseases are disorders that are characterized by a progressive decline of motor and/or cognitive functions caused by the selective degeneration and loss of neurons within the central nervous system. The most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’...

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Autores principales: Meng, Hao, Yan, Wan-Yu, Lei, Yu-Hong, Wan, Zheng, Hou, Ye-Ye, Sun, Lian-Kun, Zhou, Jue-Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861177/
https://www.ncbi.nlm.nih.gov/pubmed/31780922
http://dx.doi.org/10.3389/fnagi.2019.00313
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author Meng, Hao
Yan, Wan-Yu
Lei, Yu-Hong
Wan, Zheng
Hou, Ye-Ye
Sun, Lian-Kun
Zhou, Jue-Pu
author_facet Meng, Hao
Yan, Wan-Yu
Lei, Yu-Hong
Wan, Zheng
Hou, Ye-Ye
Sun, Lian-Kun
Zhou, Jue-Pu
author_sort Meng, Hao
collection PubMed
description Neurodegenerative diseases are disorders that are characterized by a progressive decline of motor and/or cognitive functions caused by the selective degeneration and loss of neurons within the central nervous system. The most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). Neurons have high energy demands, and dysregulation of mitochondrial quality and function is an important cause of neuronal degeneration. Mitochondrial quality control plays an important role in maintaining mitochondrial integrity and ensuring normal mitochondrial function; thus, defects in mitochondrial quality control are also significant causes of neurodegenerative diseases. The mitochondrial deacetylase SIRT3 has been found to have a large effect on mitochondrial function. Recent studies have also shown that SIRT3 has a role in mitochondrial quality control, including in the refolding or degradation of misfolded/unfolded proteins, mitochondrial dynamics, mitophagy, and mitochondrial biogenesis, all of which are affected in neurodegenerative diseases.
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spelling pubmed-68611772019-11-28 SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases Meng, Hao Yan, Wan-Yu Lei, Yu-Hong Wan, Zheng Hou, Ye-Ye Sun, Lian-Kun Zhou, Jue-Pu Front Aging Neurosci Neuroscience Neurodegenerative diseases are disorders that are characterized by a progressive decline of motor and/or cognitive functions caused by the selective degeneration and loss of neurons within the central nervous system. The most common neurodegenerative diseases are Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD). Neurons have high energy demands, and dysregulation of mitochondrial quality and function is an important cause of neuronal degeneration. Mitochondrial quality control plays an important role in maintaining mitochondrial integrity and ensuring normal mitochondrial function; thus, defects in mitochondrial quality control are also significant causes of neurodegenerative diseases. The mitochondrial deacetylase SIRT3 has been found to have a large effect on mitochondrial function. Recent studies have also shown that SIRT3 has a role in mitochondrial quality control, including in the refolding or degradation of misfolded/unfolded proteins, mitochondrial dynamics, mitophagy, and mitochondrial biogenesis, all of which are affected in neurodegenerative diseases. Frontiers Media S.A. 2019-11-12 /pmc/articles/PMC6861177/ /pubmed/31780922 http://dx.doi.org/10.3389/fnagi.2019.00313 Text en Copyright © 2019 Meng, Yan, Lei, Wan, Hou, Sun and Zhou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Meng, Hao
Yan, Wan-Yu
Lei, Yu-Hong
Wan, Zheng
Hou, Ye-Ye
Sun, Lian-Kun
Zhou, Jue-Pu
SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases
title SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases
title_full SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases
title_fullStr SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases
title_full_unstemmed SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases
title_short SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases
title_sort sirt3 regulation of mitochondrial quality control in neurodegenerative diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861177/
https://www.ncbi.nlm.nih.gov/pubmed/31780922
http://dx.doi.org/10.3389/fnagi.2019.00313
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