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Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases

Cystic kidney disease is the progressive development of multiple fluid-filled cysts that may severely compromise kidney functions and lead to renal failure. TNS1 (tensin-1) knockout mice develop cystic kidneys and die from renal failure. Here, we have established TNS1-knockout MDCK cells and applied...

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Detalles Bibliográficos
Autores principales:	Wu, Zong-Ye, Chiu, Chun-Lung, Lo, Ethan, Lee, Yuh-Ru Julie, Yamada, Soichiro, Lo, Su Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861224/ https://www.ncbi.nlm.nih.gov/pubmed/31740667 http://dx.doi.org/10.1038/s41419-019-2119-7

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