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Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers

Aurora kinase A (AURKA) is frequently overexpressed in several cancers. miRNA sequencing and bioinformatics analysis indicated significant downregulation of miR-4715-3p. We found that miR-4715-3p has putative binding sites on the 3UTR region of AURKA. Upper gastrointestinal adenocarcinoma (UGC) tiss...

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Detalles Bibliográficos
Autores principales:	Gomaa, Ahmed, Peng, Dunfa, Chen, Zheng, Soutto, Mohammed, Abouelezz, Khaled, Corvalan, Alejandro, El-Rifai, Wael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861278/ https://www.ncbi.nlm.nih.gov/pubmed/31740746 http://dx.doi.org/10.1038/s41598-019-53174-6

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