Preclinical Studies Comparing Efficacy and Toxicity of DNA Repair Inhibitors, Olaparib, and AsiDNA, in the Treatment of Carboplatin-Resistant Tumors

Purpose: Carboplatin is used to treat many cancers, but occurrence of drug resistance and its high toxicity remain a clinical hurdle limiting its efficacy. We compared the efficacy and toxicity of DNA repair inhibitors olaparib or AsiDNA administered alone or in combination with carboplatin. Olapari...

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Detalles Bibliográficos
Autores principales: Herath, Nirmitha I., Berthault, Nathalie, Thierry, Sylvain, Jdey, Wael, Lienafa, Marie-Christine, Bono, Françoise, Noguiez-Hellin, Patricia, Sun, Jian-Sheng, Dutreix, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861330/
https://www.ncbi.nlm.nih.gov/pubmed/31781480
http://dx.doi.org/10.3389/fonc.2019.01097

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