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Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors

AIMS/HYPOTHESIS: This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. METHODS: A case-cohort study wit...

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Autores principales: Wittenbecher, Clemens, Kuxhaus, Olga, Boeing, Heiner, Stefan, Norbert, Schulze, Matthias B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861343/
https://www.ncbi.nlm.nih.gov/pubmed/31501920
http://dx.doi.org/10.1007/s00125-019-04978-8
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author Wittenbecher, Clemens
Kuxhaus, Olga
Boeing, Heiner
Stefan, Norbert
Schulze, Matthias B.
author_facet Wittenbecher, Clemens
Kuxhaus, Olga
Boeing, Heiner
Stefan, Norbert
Schulze, Matthias B.
author_sort Wittenbecher, Clemens
collection PubMed
description AIMS/HYPOTHESIS: This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. METHODS: A case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study comprising 26,437 participants who provided blood samples was designed. We randomly selected a subcohort of 2500 individuals (2029 diabetes-free at baseline and with anamnestic, anthropometrical and metabolic data for analysis). Of the 820 incident diabetes cases identified in the full cohort during 7 years of follow-up, 698 remained for analyses after similar exclusions. RESULTS: After adjustment for age, potential lifestyle confounders, education and waist circumference, greater height was related to lower diabetes risk (HR per 10 cm, men 0.59 [95% CI 0.47, 0.75] and women 0.67 [0.51, 0.88], respectively). Leg length was related to lower risk among men and women, but only among men if adjusted for total height. Adjustment for liver fat and triacylglycerols, adiponectin and C-reactive protein substantially attenuated associations between height and diabetes risk, particularly among women. CONCLUSIONS/INTERPRETATION: We observed inverse associations between height and risk of type 2 diabetes, which was largely related to leg length among men. The inverse associations may be partly driven by lower liver fat content and a more favourable cardiometabolic profile. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-019-04978-8) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
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spelling pubmed-68613432019-12-03 Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors Wittenbecher, Clemens Kuxhaus, Olga Boeing, Heiner Stefan, Norbert Schulze, Matthias B. Diabetologia Article AIMS/HYPOTHESIS: This study aimed to evaluate associations of height as well as components of height (sitting height and leg length) with risk of type 2 diabetes and to explore to what extent associations are explainable by liver fat and cardiometabolic risk markers. METHODS: A case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study comprising 26,437 participants who provided blood samples was designed. We randomly selected a subcohort of 2500 individuals (2029 diabetes-free at baseline and with anamnestic, anthropometrical and metabolic data for analysis). Of the 820 incident diabetes cases identified in the full cohort during 7 years of follow-up, 698 remained for analyses after similar exclusions. RESULTS: After adjustment for age, potential lifestyle confounders, education and waist circumference, greater height was related to lower diabetes risk (HR per 10 cm, men 0.59 [95% CI 0.47, 0.75] and women 0.67 [0.51, 0.88], respectively). Leg length was related to lower risk among men and women, but only among men if adjusted for total height. Adjustment for liver fat and triacylglycerols, adiponectin and C-reactive protein substantially attenuated associations between height and diabetes risk, particularly among women. CONCLUSIONS/INTERPRETATION: We observed inverse associations between height and risk of type 2 diabetes, which was largely related to leg length among men. The inverse associations may be partly driven by lower liver fat content and a more favourable cardiometabolic profile. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-019-04978-8) contains peer-reviewed but unedited supplementary material, which is available to authorised users. Springer Berlin Heidelberg 2019-09-09 2019 /pmc/articles/PMC6861343/ /pubmed/31501920 http://dx.doi.org/10.1007/s00125-019-04978-8 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Wittenbecher, Clemens
Kuxhaus, Olga
Boeing, Heiner
Stefan, Norbert
Schulze, Matthias B.
Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors
title Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors
title_full Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors
title_fullStr Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors
title_full_unstemmed Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors
title_short Associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors
title_sort associations of short stature and components of height with incidence of type 2 diabetes: mediating effects of cardiometabolic risk factors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861343/
https://www.ncbi.nlm.nih.gov/pubmed/31501920
http://dx.doi.org/10.1007/s00125-019-04978-8
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