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Extracellular vesicles in metabolic disease

Extracellular vesicles (EVs) are submicron-sized lipid envelopes that are produced and released from a parent cell and can be taken up by a recipient cell. EVs are capable of mediating cellular signalling by carrying nucleic acids, proteins, lipids and cellular metabolites between cells and organs....

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Autores principales: Akbar, Naveed, Azzimato, Valerio, Choudhury, Robin P., Aouadi, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861353/
https://www.ncbi.nlm.nih.gov/pubmed/31690986
http://dx.doi.org/10.1007/s00125-019-05014-5
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author Akbar, Naveed
Azzimato, Valerio
Choudhury, Robin P.
Aouadi, Myriam
author_facet Akbar, Naveed
Azzimato, Valerio
Choudhury, Robin P.
Aouadi, Myriam
author_sort Akbar, Naveed
collection PubMed
description Extracellular vesicles (EVs) are submicron-sized lipid envelopes that are produced and released from a parent cell and can be taken up by a recipient cell. EVs are capable of mediating cellular signalling by carrying nucleic acids, proteins, lipids and cellular metabolites between cells and organs. Metabolic dysfunction is associated with changes in plasma concentrations of EVs as well as alterations in their EV cargo. Since EVs can act as messengers between parent and recipient cells, they could be involved in cell-to-cell and organ-to-organ communication in metabolic diseases. Recent literature has shown that EVs are produced by cells within metabolic tissues, such as adipose tissue, pancreas, muscle and liver. These vesicles have therefore been proposed as a novel intercellular communication mode in systemic metabolic regulation. In this review, we will describe and discuss the current literature that investigates the role of adipose-derived EVs in the regulation of obesity-associated metabolic disease. We will particularly focus on the EV-dependent communication between adipocytes, the vasculature and immune cells in type 2 diabetes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-019-05014-5) contains a slide of the figure for download, which is available to authorised users.
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spelling pubmed-68613532019-12-03 Extracellular vesicles in metabolic disease Akbar, Naveed Azzimato, Valerio Choudhury, Robin P. Aouadi, Myriam Diabetologia Review Extracellular vesicles (EVs) are submicron-sized lipid envelopes that are produced and released from a parent cell and can be taken up by a recipient cell. EVs are capable of mediating cellular signalling by carrying nucleic acids, proteins, lipids and cellular metabolites between cells and organs. Metabolic dysfunction is associated with changes in plasma concentrations of EVs as well as alterations in their EV cargo. Since EVs can act as messengers between parent and recipient cells, they could be involved in cell-to-cell and organ-to-organ communication in metabolic diseases. Recent literature has shown that EVs are produced by cells within metabolic tissues, such as adipose tissue, pancreas, muscle and liver. These vesicles have therefore been proposed as a novel intercellular communication mode in systemic metabolic regulation. In this review, we will describe and discuss the current literature that investigates the role of adipose-derived EVs in the regulation of obesity-associated metabolic disease. We will particularly focus on the EV-dependent communication between adipocytes, the vasculature and immune cells in type 2 diabetes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-019-05014-5) contains a slide of the figure for download, which is available to authorised users. Springer Berlin Heidelberg 2019-11-05 2019 /pmc/articles/PMC6861353/ /pubmed/31690986 http://dx.doi.org/10.1007/s00125-019-05014-5 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Akbar, Naveed
Azzimato, Valerio
Choudhury, Robin P.
Aouadi, Myriam
Extracellular vesicles in metabolic disease
title Extracellular vesicles in metabolic disease
title_full Extracellular vesicles in metabolic disease
title_fullStr Extracellular vesicles in metabolic disease
title_full_unstemmed Extracellular vesicles in metabolic disease
title_short Extracellular vesicles in metabolic disease
title_sort extracellular vesicles in metabolic disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861353/
https://www.ncbi.nlm.nih.gov/pubmed/31690986
http://dx.doi.org/10.1007/s00125-019-05014-5
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