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Tumor-infiltrating lymphocytes and CD8(+) T cells predict survival of triple-negative breast cancer
PURPOSE: Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. METHODS: TNBC patients (n = 179) with complete clinical data and up...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861359/ https://www.ncbi.nlm.nih.gov/pubmed/31562550 http://dx.doi.org/10.1007/s00432-019-03036-5 |
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author | Vihervuori, H. Autere, T. A. Repo, H. Kurki, S. Kallio, L. Lintunen, M. M. Talvinen, K. Kronqvist, P. |
author_facet | Vihervuori, H. Autere, T. A. Repo, H. Kurki, S. Kallio, L. Lintunen, M. M. Talvinen, K. Kronqvist, P. |
author_sort | Vihervuori, H. |
collection | PubMed |
description | PURPOSE: Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. METHODS: TNBC patients (n = 179) with complete clinical data and up to 18-year follow-up were obtained from Auria biobank, Turku University Hospital, Turku, Finland. Tumor-infiltrating lymphocytes (TILs) and several subtypes of inflammatory cells detected with immunohistochemistry were evaluated in different tumor compartments in full tissue sections and tissue microarrays. RESULTS: Deficiency of stromal TILs and low number of CD8(+) T cells independently predicted mortality in TNBC (HR 2.4, p 0.02 and HR 2.1, p 0.02, respectively). Each 10% decrease in stromal TILs resulted in 20% increased risk of mortality. An average of 13.2-year survival difference was observed between the majority (> 75%) of patients with low (< 14% of TILs) vs high (≥ 14% of TILs) frequency of CD8(+) T cells. The prognostic value of TILs and CD8(+) T cells varied when evaluated in different tumor compartments. TILs and CD8(+) T cells were significantly associated with Securin and Separase, essential regulators of metaphase–anaphase transition of the cell cycle. DISCUSSION: TILs and CD8(+) T cells provide additional prognostic value to the established clinical prognostic markers in TNBC. However, possible clinical applications would still benefit from systematic guidelines for evaluating tumor inflammatory response. Increasing understanding on the interactions between the regulation of cancer cell proliferation and inflammatory response may in future advance treatment of TNBC. |
format | Online Article Text |
id | pubmed-6861359 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-68613592019-12-03 Tumor-infiltrating lymphocytes and CD8(+) T cells predict survival of triple-negative breast cancer Vihervuori, H. Autere, T. A. Repo, H. Kurki, S. Kallio, L. Lintunen, M. M. Talvinen, K. Kronqvist, P. J Cancer Res Clin Oncol Original Article – Clinical Oncology PURPOSE: Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. METHODS: TNBC patients (n = 179) with complete clinical data and up to 18-year follow-up were obtained from Auria biobank, Turku University Hospital, Turku, Finland. Tumor-infiltrating lymphocytes (TILs) and several subtypes of inflammatory cells detected with immunohistochemistry were evaluated in different tumor compartments in full tissue sections and tissue microarrays. RESULTS: Deficiency of stromal TILs and low number of CD8(+) T cells independently predicted mortality in TNBC (HR 2.4, p 0.02 and HR 2.1, p 0.02, respectively). Each 10% decrease in stromal TILs resulted in 20% increased risk of mortality. An average of 13.2-year survival difference was observed between the majority (> 75%) of patients with low (< 14% of TILs) vs high (≥ 14% of TILs) frequency of CD8(+) T cells. The prognostic value of TILs and CD8(+) T cells varied when evaluated in different tumor compartments. TILs and CD8(+) T cells were significantly associated with Securin and Separase, essential regulators of metaphase–anaphase transition of the cell cycle. DISCUSSION: TILs and CD8(+) T cells provide additional prognostic value to the established clinical prognostic markers in TNBC. However, possible clinical applications would still benefit from systematic guidelines for evaluating tumor inflammatory response. Increasing understanding on the interactions between the regulation of cancer cell proliferation and inflammatory response may in future advance treatment of TNBC. Springer Berlin Heidelberg 2019-09-27 2019 /pmc/articles/PMC6861359/ /pubmed/31562550 http://dx.doi.org/10.1007/s00432-019-03036-5 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article – Clinical Oncology Vihervuori, H. Autere, T. A. Repo, H. Kurki, S. Kallio, L. Lintunen, M. M. Talvinen, K. Kronqvist, P. Tumor-infiltrating lymphocytes and CD8(+) T cells predict survival of triple-negative breast cancer |
title | Tumor-infiltrating lymphocytes and CD8(+) T cells predict survival of triple-negative breast cancer |
title_full | Tumor-infiltrating lymphocytes and CD8(+) T cells predict survival of triple-negative breast cancer |
title_fullStr | Tumor-infiltrating lymphocytes and CD8(+) T cells predict survival of triple-negative breast cancer |
title_full_unstemmed | Tumor-infiltrating lymphocytes and CD8(+) T cells predict survival of triple-negative breast cancer |
title_short | Tumor-infiltrating lymphocytes and CD8(+) T cells predict survival of triple-negative breast cancer |
title_sort | tumor-infiltrating lymphocytes and cd8(+) t cells predict survival of triple-negative breast cancer |
topic | Original Article – Clinical Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861359/ https://www.ncbi.nlm.nih.gov/pubmed/31562550 http://dx.doi.org/10.1007/s00432-019-03036-5 |
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