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Pregnancy History, Hypertension, and Cognitive Impairment in Postmenopausal Women

PURPOSE OF REVIEW: Risks for developing cardiovascular disease and cognitive decline increase with age. In women, these risks may be influenced by pregnancy history. This review provides an integrated evaluation of associations of pregnancy history with hypertension, brain atrophy, and cognitive dec...

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Autores principales: Miller, Kathleen B., Miller, Virginia M., Barnes, Jill N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861362/
https://www.ncbi.nlm.nih.gov/pubmed/31741134
http://dx.doi.org/10.1007/s11906-019-0997-9
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author Miller, Kathleen B.
Miller, Virginia M.
Barnes, Jill N.
author_facet Miller, Kathleen B.
Miller, Virginia M.
Barnes, Jill N.
author_sort Miller, Kathleen B.
collection PubMed
description PURPOSE OF REVIEW: Risks for developing cardiovascular disease and cognitive decline increase with age. In women, these risks may be influenced by pregnancy history. This review provides an integrated evaluation of associations of pregnancy history with hypertension, brain atrophy, and cognitive decline in postmenopausal women. RECENT FINDINGS: Atrophy in the occipital lobes of the brain was evident in women who had current hypertension and a history of preeclampsia. Deficits in visual memory in women with a history of preeclampsia are consistent with these brain structural changes. The blood velocity response to chemical and sympathoexcitatory stimuli were altered in women with a history of preeclampsia linking impairments in cerebrovascular regulation to the structural and functional changes in the brain. SUMMARY: Having a history of preeclampsia should require close monitoring of blood pressure and initiation of anti-hypertensive treatment in perimenopausal women. Mechanisms by which preeclampsia affects cerebrovascular structure and function require additional study.
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spelling pubmed-68613622019-12-03 Pregnancy History, Hypertension, and Cognitive Impairment in Postmenopausal Women Miller, Kathleen B. Miller, Virginia M. Barnes, Jill N. Curr Hypertens Rep Secondary Hypertension: Nervous System Mechanisms (JM Wyss, Section Editor) PURPOSE OF REVIEW: Risks for developing cardiovascular disease and cognitive decline increase with age. In women, these risks may be influenced by pregnancy history. This review provides an integrated evaluation of associations of pregnancy history with hypertension, brain atrophy, and cognitive decline in postmenopausal women. RECENT FINDINGS: Atrophy in the occipital lobes of the brain was evident in women who had current hypertension and a history of preeclampsia. Deficits in visual memory in women with a history of preeclampsia are consistent with these brain structural changes. The blood velocity response to chemical and sympathoexcitatory stimuli were altered in women with a history of preeclampsia linking impairments in cerebrovascular regulation to the structural and functional changes in the brain. SUMMARY: Having a history of preeclampsia should require close monitoring of blood pressure and initiation of anti-hypertensive treatment in perimenopausal women. Mechanisms by which preeclampsia affects cerebrovascular structure and function require additional study. Springer US 2019-11-18 2019 /pmc/articles/PMC6861362/ /pubmed/31741134 http://dx.doi.org/10.1007/s11906-019-0997-9 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Secondary Hypertension: Nervous System Mechanisms (JM Wyss, Section Editor)
Miller, Kathleen B.
Miller, Virginia M.
Barnes, Jill N.
Pregnancy History, Hypertension, and Cognitive Impairment in Postmenopausal Women
title Pregnancy History, Hypertension, and Cognitive Impairment in Postmenopausal Women
title_full Pregnancy History, Hypertension, and Cognitive Impairment in Postmenopausal Women
title_fullStr Pregnancy History, Hypertension, and Cognitive Impairment in Postmenopausal Women
title_full_unstemmed Pregnancy History, Hypertension, and Cognitive Impairment in Postmenopausal Women
title_short Pregnancy History, Hypertension, and Cognitive Impairment in Postmenopausal Women
title_sort pregnancy history, hypertension, and cognitive impairment in postmenopausal women
topic Secondary Hypertension: Nervous System Mechanisms (JM Wyss, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861362/
https://www.ncbi.nlm.nih.gov/pubmed/31741134
http://dx.doi.org/10.1007/s11906-019-0997-9
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