Cargando…

Circulating metabolites and the risk of type 2 diabetes: a prospective study of 11,896 young adults from four Finnish cohorts

AIMS/HYPOTHESIS: Metabolomics technologies have identified numerous blood biomarkers for type 2 diabetes risk in case−control studies of middle-aged and older individuals. We aimed to validate existing and identify novel metabolic biomarkers predictive of future diabetes in large cohorts of young ad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahola-Olli, Ari V., Mustelin, Linda, Kalimeri, Maria, Kettunen, Johannes, Jokelainen, Jari, Auvinen, Juha, Puukka, Katri, Havulinna, Aki S., Lehtimäki, Terho, Kähönen, Mika, Juonala, Markus, Keinänen-Kiukaanniemi, Sirkka, Salomaa, Veikko, Perola, Markus, Järvelin, Marjo-Riitta, Ala-Korpela, Mika, Raitakari, Olli, Würtz, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861432/ https://www.ncbi.nlm.nih.gov/pubmed/31584131 http://dx.doi.org/10.1007/s00125-019-05001-w

Ejemplares similares

Insulin resistance and systemic metabolic changes in oral glucose tolerance test in 5340 individuals: an interventional study
por: Wang, Qin, et al.
Publicado: (2019)

Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns
por: Sliz, Eeva, et al.
Publicado: (2019)

Longitudinal metabolomics of increasing body-mass index and waist-hip ratio reveals two dynamic patterns of obesity pandemic
por: Mäkinen, Ville-Petteri, et al.
Publicado: (2023)

Systematic evaluation of the association between hemoglobin levels and metabolic profile implicates beneficial effects of hypoxia
por: Auvinen, Juha, et al.
Publicado: (2021)

Cross-sectionally Calculated Metabolic Aging Does Not Relate to Longitudinal Metabolic Changes—Support for Stratified Aging Models
por: Ala-Korpela, Mika, et al.
Publicado: (2023)

Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis
por: Wang, Qin, et al.
Publicado: (2020)

Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population
por: Salo, Perttu P., et al.
Publicado: (2017)

Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence
por: Wang, Qin, et al.
Publicado: (2016)

Genetic and observational evidence: No independent role for cholesterol efflux over static high‐density lipoprotein concentration measures in coronary heart disease risk assessment
por: Kuusisto, Sanna, et al.
Publicado: (2022)

Abnormal skin in toe webs is a marker for abnormal glucose metabolism. A cross-sectional survey among 1,849 adults in Finland
por: Sinikumpu, Suvi-Päivikki, et al.
Publicado: (2017)

Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence
por: Wang, Qin, et al.
Publicado: (2016)

An interaction map of circulating metabolites, immune gene networks, and their genetic regulation
por: Nath, Artika P., et al.
Publicado: (2017)

The effect of apolipoprotein E polymorphism on serum metabolome – a population-based 10-year follow-up study
por: Karjalainen, Juho-Pekka, et al.
Publicado: (2019)

Vitamin D Status and Components of Metabolic Syndrome in Older Subjects from Northern Finland (Latitude 65°North)
por: Mutt, Shivaprakash Jagalur, et al.
Publicado: (2019)

Association between mitochondrial DNA haplogroups J and K, serum branched-chain amino acids and lowered capability for endurance exercise
por: Kiiskilä, Jukka M., et al.
Publicado: (2022)

Genome-Wide Meta-Analysis of Sciatica in Finnish Population
por: Lemmelä, Susanna, et al.
Publicado: (2016)

Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease: An Observational Analysis and Mendelian Randomization
por: Huang, Jian, et al.
Publicado: (2023)

Carotid artery elasticity decreases during pregnancy - the Cardiovascular Risk in Young Finns study
por: Kärkkäinen, Henna, et al.
Publicado: (2014)

The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease
por: Kalaoja, Marita, et al.
Publicado: (2021)

Metabolic profiling of alcohol consumption in 9778 young adults
por: Würtz, Peter, et al.
Publicado: (2016)

No Association of nineteenCOX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study
por: Lähteelä, Kati, et al.
Publicado: (2012)

Glucose status and depressive symptoms: a cohort study of elderly people in northwest Finland
por: Perkkiö, Yrjö, et al.
Publicado: (2019)

Cardiovascular disease risk and all-cause mortality associated with accelerometer-measured physical activity and sedentary time ‒ a prospective population-based study in older adults
por: Länsitie, Miia, et al.
Publicado: (2022)

PCSK9 Levels and Metabolic Profiles in Elderly Subjects with Different Glucose Tolerance under Statin Therapy
por: Mäkelä, Kari A., et al.
Publicado: (2021)

Gene Set Based Integrated Methylome and Transcriptome Analysis Reveals Potential Molecular Mechanisms Linking Cigarette Smoking and Related Diseases
por: Mishra, Pashupati P., et al.
Publicado: (2023)

Assessment of plasma ceramides as predictor for subclinical atherosclerosis
por: Mishra, Pashupati P., et al.
Publicado: (2021)

Cardiometabolic Health Among Adult Offspring of Hypertensive Pregnancies: The Cardiovascular Risk in Young Finns Study
por: Tapp, Robyn J., et al.
Publicado: (2018)

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects
por: Sliz, Eeva, et al.
Publicado: (2018)

Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase
por: Würtz, Peter, et al.
Publicado: (2016)

Metabolic profiling of fatty liver in young and middle‐aged adults: Cross‐sectional and prospective analyses of the Young Finns Study
por: Kaikkonen, Jari E., et al.
Publicado: (2016)

Factors predicting 31-year survival among a population cohort in Northern Finland
por: Perkkiö, Yrjö, et al.
Publicado: (2021)

Association of Physical Activity in Childhood and Early Adulthood With Carotid Artery Elasticity 21 Years Later: The Cardiovascular Risk in Young Finns Study
por: Pälve, Kristiina S., et al.
Publicado: (2014)

Subtle increases in heart size persist into adulthood in growth restricted babies: the Cardiovascular Risk in Young Finns Study
por: Arnott, Clare, et al.
Publicado: (2015)

Elevated serum alpha-1 antitrypsin is a major component of GlycA-associated risk for future morbidity and mortality
por: Ritchie, Scott C., et al.
Publicado: (2019)

Skin cancers and their risk factors in older persons: a population-based study
por: Sinikumpu, Suvi-Päivikki, et al.
Publicado: (2022)

Prospective Relationship of Change in Ideal Cardiovascular Health Status and Arterial Stiffness: The Cardiovascular Risk in Young Finns Study
por: Aatola, Heikki, et al.
Publicado: (2014)

Association of Childhood Oral Infections With Cardiovascular Risk Factors and Subclinical Atherosclerosis in Adulthood
por: Pussinen, Pirkko J., et al.
Publicado: (2019)

The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis
por: Seppälä, Ilkka, et al.
Publicado: (2017)

Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study
por: Campbell, Matthew D., et al.
Publicado: (2018)

Cardiovascular disease risk factors in relation to smoking behaviour and history: a population-based cohort study
por: Keto, Jaana, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2l6rmisfv0mnvohkcf5ee5v5mo