Cargando…

The MAP2K4/JNK/c-Jun Signaling Pathway Plays A Key Role In Dexmedetomidine Protection Against Acetaminophen-Induced Liver Toxicity

PURPOSE: Dexmedetomidine [DEX; (S)-4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole] is a selective α(2)-adrenergic receptor (α(2)-AR) agonist that attenuates the liver damage associated with local or systemic inflammation. However, it remains unclear whether DEX has protective effects against acetamino...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chou, An-Hsun, Liao, Chia-Chih, Lee, Hung-Chen, Liou, Jiin-Tarng, Liu, Fu-Chao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861533/ https://www.ncbi.nlm.nih.gov/pubmed/31814709 http://dx.doi.org/10.2147/DDDT.S215473

Ejemplares similares

Baicalin Attenuates IL-17-Mediated Acetaminophen-Induced Liver Injury in a Mouse Model
por: Liao, Chia-Chih, et al.
Publicado: (2016)

ERK/NF-kB/COX-2 Signaling Pathway Plays a Key Role in Curcumin Protection against Acetaminophen-Induced Liver Injury
por: Chou, An-Hsun, et al.
Publicado: (2023)

The Timing and Effects of Low-Dose Ethanol Treatment on Acetaminophen-Induced Liver Injury
por: Liu, Fu-Chao, et al.
Publicado: (2021)

C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media
por: Yao, William, et al.
Publicado: (2014)

Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways
por: Liu, Fu-Chao, et al.
Publicado: (2016)

p-Hydroxybenzyl Alcohol Antagonized the ROS-Dependent JNK/Jun/Caspase-3 Pathway to Produce Neuroprotection in a Cellular Model of Parkinson’s Disease
por: Lai, Mei-Chou, et al.
Publicado: (2022)

C-C Chemokine Ligand-5 is critical for facilitating macrophage infiltration in the early phase of liver ischemia/reperfusion injury
por: Lee, Chiou-Mei, et al.
Publicado: (2017)

Protective Role of microRNA-31 in Acetaminophen-Induced Liver Injury: A Negative Regulator of c-Jun N-Terminal Kinase (JNK) Signaling Pathway
por: Zheng, Jianxin, et al.
Publicado: (2021)

Role of NADPH Oxidase-Derived ROS-Mediated IL-6/STAT3 and MAPK/NF-κB Signaling Pathways in Protective Effect of Corilagin against Acetaminophen-Induced Liver Injury in Mice
por: Liu, Fu-Chao, et al.
Publicado: (2023)

Outcomes of patients with acetaminophen-associated toxic hepatitis at a far east poison center
por: Hou, Yi-Chou, et al.
Publicado: (2013)

Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation
por: Anfinogenova, Nina D., et al.
Publicado: (2020)

The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
por: Chen, Jing, et al.
Publicado: (2021)

UTRN inhibits melanoma growth by suppressing p38 and JNK/c-Jun signaling pathways
por: Zhou, Sitong, et al.
Publicado: (2021)

Stressor-Like Effects of c-Jun N-Terminal Kinase (JNK) Inhibition
por: Clarke, Melanie, et al.
Publicado: (2012)

Nerve Injury-Induced c-Jun Activation in Schwann Cells Is JNK Independent
por: Lindwall Blom, Charlotta, et al.
Publicado: (2014)

MALT1 promotes melanoma progression through JNK/c-Jun signaling
por: Wang, Y, et al.
Publicado: (2017)

Activation of c-Jun by human cytomegalovirus UL42 through JNK activation
por: Koshizuka, Tetsuo, et al.
Publicado: (2020)

Peroxiredoxin 6 mediates acetaminophen-induced hepatocyte death through JNK activation
por: Lee, Dong Hun, et al.
Publicado: (2020)

Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity
por: James, Laura, et al.
Publicado: (2015)

Acetaminophen toxicity: suicidal vs accidental
por: Gyamlani, Geeta G, et al.
Publicado: (2002)

Molecular docking of C-Jun-N-Terminal Kinase (Jnk) with amino-pyrimidine derivatives
por: Meenakumari, Krishnamoorthy, et al.
Publicado: (2020)

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
por: Yung, Justin Hou Ming, et al.
Publicado: (2020)

TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway
por: Wang, Shu-Yang, et al.
Publicado: (2015)

c-Jun NH(2)-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8(+) T Cell Activation
por: Conze, Dietrich, et al.
Publicado: (2002)

CFIm25 inhibits hepatocellular carcinoma metastasis by suppressing the p38 and JNK/c-Jun signaling pathways
por: Wang, Yunwu, et al.
Publicado: (2018)

Intraoperative Administration of Intravenous Dexmedetomidine and Acetaminophen for Improved Postoperative Pain Management in Primary Palatoplasty
por: Ichiuji, Brynne, et al.
Publicado: (2020)

Perioperative Acetaminophen and Dexmedetomidine Eliminate Post-Operative Opioid Requirement following Pediatric Tonsillectomy
por: Rudikoff, Andrew G., et al.
Publicado: (2022)

Basal Cancer Cell Survival Involves JNK2 Suppression of a Novel JNK1/c-Jun/Bcl-3 Apoptotic Network
por: Ahmed, Shafiq Uddin, et al.
Publicado: (2009)

Activation of c-Jun N-Terminal Kinase (JNK) during Mitosis in Retinal Progenitor Cells
por: Ribas, Vinicius Toledo, et al.
Publicado: (2012)

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease
por: Yarza, Ramon, et al.
Publicado: (2016)

Overexpressed DNA Polymerase Iota Regulated by JNK/c-Jun Contributes to Hypermutagenesis in Bladder Cancer
por: Yuan, Fang, et al.
Publicado: (2013)

Tenascin-C induces migration and invasion through JNK/c-Jun signalling in pancreatic cancer
por: Cai, Jun, et al.
Publicado: (2017)

Targeting c-MET by Tivantinib through synergistic activation of JNK/c-jun pathway in cholangiocarcinoma
por: Wei, Kai, et al.
Publicado: (2019)

BUB1B promotes extrahepatic cholangiocarcinoma progression via JNK/c-Jun pathways
por: Jiao, Chen Yu, et al.
Publicado: (2021)

Glucocorticoids induce femoral head necrosis in rats through the ROS/JNK/c‐Jun pathway
por: Peng, Puji, et al.
Publicado: (2020)

c-JUN n-Terminal Kinase (JNK) Signaling in Autosomal Dominant Polycystic Kidney Disease
por: Smith, Abigail O., et al.
Publicado: (2022)

RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway
por: Zhang, Deyu, et al.
Publicado: (2021)

Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors
por: Schepetkin, Igor A., et al.
Publicado: (2023)

Acetaminophen Toxicity: When to Consult the Transplant Surgeon
por: Sebastian, Raynard J., et al.
Publicado: (2000)

Identification of Identical Transcript Changes in Liver and Whole Blood during Acetaminophen Toxicity
por: Zhang, Liwen, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_vcomau8sapamrils6hgnrp8fkc