Peptide-Targeted Polyplexes for Aerosol-Mediated Gene Delivery to CD49f-Overexpressing Tumor Lesions in Lung

Peptide ligands can enhance delivery of nucleic acid-loaded nanoparticles to tumors by promoting their cell binding and internalization. Lung tumor lesions accessible from the alveolar side can be transfected, in principle, using gene vectors delivered as an aerosol. The cell surface marker CD49f (I...

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Detalles Bibliográficos
Autores principales: Taschauer, Alexander, Polzer, Wolfram, Alioglu, Fatih, Billerhart, Magdalena, Decker, Simon, Kittelmann, Theresa, Geppl, Emanuela, Elmenofi, Salma, Zehl, Martin, Urban, Ernst, Sami, Haider, Ogris, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861568/
https://www.ncbi.nlm.nih.gov/pubmed/31734558
http://dx.doi.org/10.1016/j.omtn.2019.10.009

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