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In-vivo performance of plasma-sprayed CaO–MgO–SiO(2)-based bioactive glass-ceramic coating on Ti–6Al–4V alloy for bone regeneration
The CaO–MgO–SiO(2)-based bioactive glass-ceramic coating (named M2) on Ti–6Al–4V alloy has been proven to behave well in vitro. But how to make full sense of its performances in terms of osteogenesis and osseointegration in vivo matters very much. For this, the M2-coated Ti–6Al–4V cylinders were pre...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861571/ https://www.ncbi.nlm.nih.gov/pubmed/31763479 http://dx.doi.org/10.1016/j.heliyon.2019.e02824 |
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author | Zhang, Mengjiao Pu, Ximing Chen, Xianchun Yin, Guangfu |
author_facet | Zhang, Mengjiao Pu, Ximing Chen, Xianchun Yin, Guangfu |
author_sort | Zhang, Mengjiao |
collection | PubMed |
description | The CaO–MgO–SiO(2)-based bioactive glass-ceramic coating (named M2) on Ti–6Al–4V alloy has been proven to behave well in vitro. But how to make full sense of its performances in terms of osteogenesis and osseointegration in vivo matters very much. For this, the M2-coated Ti–6Al–4V cylinders were prepared by atmospheric plasma spraying (APS) and implanted into New Zealand rabbit for 1, 2 and 3 months, respectively, by setting commercial HA-coated Ti–6Al–4V as the control. It is encouraging that, the two groups bonded with the surrounding tissues stably and newly formed bone grew towards or around the implants after 3-month implantation according to radiographic images. From the histological sections, it is obvious that, compared to the control, the M2-coated implant was more favorable for the osteogenesis and neo-vascularisation in the whole experimental process and demonstrated a better osseointegration with the host bone, indicating the former possessed better osteoconductivity, osteoinductivity and osteogenic ability. The study indicated that the M2-coated Ti–6Al–4V implant exerted a great potential to substitute the commercial HA-coated Ti–6Al–4V implant in repairing load-bearing bone defects. |
format | Online Article Text |
id | pubmed-6861571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68615712019-11-22 In-vivo performance of plasma-sprayed CaO–MgO–SiO(2)-based bioactive glass-ceramic coating on Ti–6Al–4V alloy for bone regeneration Zhang, Mengjiao Pu, Ximing Chen, Xianchun Yin, Guangfu Heliyon Article The CaO–MgO–SiO(2)-based bioactive glass-ceramic coating (named M2) on Ti–6Al–4V alloy has been proven to behave well in vitro. But how to make full sense of its performances in terms of osteogenesis and osseointegration in vivo matters very much. For this, the M2-coated Ti–6Al–4V cylinders were prepared by atmospheric plasma spraying (APS) and implanted into New Zealand rabbit for 1, 2 and 3 months, respectively, by setting commercial HA-coated Ti–6Al–4V as the control. It is encouraging that, the two groups bonded with the surrounding tissues stably and newly formed bone grew towards or around the implants after 3-month implantation according to radiographic images. From the histological sections, it is obvious that, compared to the control, the M2-coated implant was more favorable for the osteogenesis and neo-vascularisation in the whole experimental process and demonstrated a better osseointegration with the host bone, indicating the former possessed better osteoconductivity, osteoinductivity and osteogenic ability. The study indicated that the M2-coated Ti–6Al–4V implant exerted a great potential to substitute the commercial HA-coated Ti–6Al–4V implant in repairing load-bearing bone defects. Elsevier 2019-11-15 /pmc/articles/PMC6861571/ /pubmed/31763479 http://dx.doi.org/10.1016/j.heliyon.2019.e02824 Text en © 2019 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Zhang, Mengjiao Pu, Ximing Chen, Xianchun Yin, Guangfu In-vivo performance of plasma-sprayed CaO–MgO–SiO(2)-based bioactive glass-ceramic coating on Ti–6Al–4V alloy for bone regeneration |
title | In-vivo performance of plasma-sprayed CaO–MgO–SiO(2)-based bioactive glass-ceramic coating on Ti–6Al–4V alloy for bone regeneration |
title_full | In-vivo performance of plasma-sprayed CaO–MgO–SiO(2)-based bioactive glass-ceramic coating on Ti–6Al–4V alloy for bone regeneration |
title_fullStr | In-vivo performance of plasma-sprayed CaO–MgO–SiO(2)-based bioactive glass-ceramic coating on Ti–6Al–4V alloy for bone regeneration |
title_full_unstemmed | In-vivo performance of plasma-sprayed CaO–MgO–SiO(2)-based bioactive glass-ceramic coating on Ti–6Al–4V alloy for bone regeneration |
title_short | In-vivo performance of plasma-sprayed CaO–MgO–SiO(2)-based bioactive glass-ceramic coating on Ti–6Al–4V alloy for bone regeneration |
title_sort | in-vivo performance of plasma-sprayed cao–mgo–sio(2)-based bioactive glass-ceramic coating on ti–6al–4v alloy for bone regeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861571/ https://www.ncbi.nlm.nih.gov/pubmed/31763479 http://dx.doi.org/10.1016/j.heliyon.2019.e02824 |
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