Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress

A hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical library screening approach to identify molecules that disrupted nutrient metabolism (by increasing cell...

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Detalles Bibliográficos
Autores principales: Byrne, Frances L., Olzomer, Ellen M., Marriott, Gabriella R., Quek, Lake-Ee, Katen, Alice, Su, Jacky, Nelson, Marin E., Hart-Smith, Gene, Larance, Mark, Sebesfi, Veronica F., Cuff, Jeff, Martyn, Gabriella E., Childress, Elizabeth, Alexopoulos, Stephanie J., Poon, Ivan K., Faux, Maree C., Burgess, Antony W., Reid, Glen, McCarroll, Joshua A., Santos, Webster L., Quinlan, Kate GR., Turner, Nigel, Fazakerley, Daniel J., Kumar, Naresh, Hoehn, Kyle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861633/
https://www.ncbi.nlm.nih.gov/pubmed/31743887
http://dx.doi.org/10.1016/j.redox.2019.101374

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