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Effect of Byrsonima sericea DC. leaf extracts on mice gastrointestinal tract

Byrsonima sericea DC. (Malpighiaceae) leaves are popularly folk medicine in Brazil used to treat gastro-intestinal disorders including diarrhea and gastric diseases. Ethanol extract (BSEE), ethyl acetate extract (BSEAE) and hexane extract (BSHE) of the leaf part of Byrsonima sericea DC were characte...

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Autores principales: de Araújo Rodrigues, Patrícia, de Morais, Selene Maia, Aguiar, Liza Araújo, Vila-Nova, Nadja Soares, Benjamin, Stephen Rathinaraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861650/
https://www.ncbi.nlm.nih.gov/pubmed/31763182
http://dx.doi.org/10.1016/j.toxrep.2019.10.018
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author de Araújo Rodrigues, Patrícia
de Morais, Selene Maia
Aguiar, Liza Araújo
Vila-Nova, Nadja Soares
Benjamin, Stephen Rathinaraj
author_facet de Araújo Rodrigues, Patrícia
de Morais, Selene Maia
Aguiar, Liza Araújo
Vila-Nova, Nadja Soares
Benjamin, Stephen Rathinaraj
author_sort de Araújo Rodrigues, Patrícia
collection PubMed
description Byrsonima sericea DC. (Malpighiaceae) leaves are popularly folk medicine in Brazil used to treat gastro-intestinal disorders including diarrhea and gastric diseases. Ethanol extract (BSEE), ethyl acetate extract (BSEAE) and hexane extract (BSHE) of the leaf part of Byrsonima sericea DC were characterized for their total phenolics, proanthocyanidins and flavonoids content. The total antioxidant capacity of extracts was determined. The ethnopharmacological use of B. sericea leaves was evaluated by assaying BSEE for gastroprotective activity in stomach ulcer induced by indomethacin, intestinal motility and toxicity. Abundance of phenols mainly tannins was found in BSEE. Total phenolics, flavonoids and proanthocyanidins content in BSEE were found to be 0.371, 0.172 and 1.3 × 10-4 (mg/g) respectively. BSEE showed concentration dependent significant scavenging of DPPH values 90.0 (%) respectively. Moreover, oral doses of 500 and 1000 mg/kg did not cause mortality, and there was no difference in animals weight, organs relative weight and alanine transaminase (ALT) and aspartate transaminase (AST), as compared to the control group. Doses of 250, 500 and 1000 mg/kg inhibited the gastric lesions induced by indomethacin in 52, 60 and 62 % respectively. The dose of 1000 mg/kg decreased intestinal motility in animals. The presence of phenolic compounds, including tannins could be associated with the anti-diarrheal action and the antioxidant properties could collaborate to the gastroprotective and anti- diarrheal activities, confirming its popular use of the plant.
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spelling pubmed-68616502019-11-22 Effect of Byrsonima sericea DC. leaf extracts on mice gastrointestinal tract de Araújo Rodrigues, Patrícia de Morais, Selene Maia Aguiar, Liza Araújo Vila-Nova, Nadja Soares Benjamin, Stephen Rathinaraj Toxicol Rep Article Byrsonima sericea DC. (Malpighiaceae) leaves are popularly folk medicine in Brazil used to treat gastro-intestinal disorders including diarrhea and gastric diseases. Ethanol extract (BSEE), ethyl acetate extract (BSEAE) and hexane extract (BSHE) of the leaf part of Byrsonima sericea DC were characterized for their total phenolics, proanthocyanidins and flavonoids content. The total antioxidant capacity of extracts was determined. The ethnopharmacological use of B. sericea leaves was evaluated by assaying BSEE for gastroprotective activity in stomach ulcer induced by indomethacin, intestinal motility and toxicity. Abundance of phenols mainly tannins was found in BSEE. Total phenolics, flavonoids and proanthocyanidins content in BSEE were found to be 0.371, 0.172 and 1.3 × 10-4 (mg/g) respectively. BSEE showed concentration dependent significant scavenging of DPPH values 90.0 (%) respectively. Moreover, oral doses of 500 and 1000 mg/kg did not cause mortality, and there was no difference in animals weight, organs relative weight and alanine transaminase (ALT) and aspartate transaminase (AST), as compared to the control group. Doses of 250, 500 and 1000 mg/kg inhibited the gastric lesions induced by indomethacin in 52, 60 and 62 % respectively. The dose of 1000 mg/kg decreased intestinal motility in animals. The presence of phenolic compounds, including tannins could be associated with the anti-diarrheal action and the antioxidant properties could collaborate to the gastroprotective and anti- diarrheal activities, confirming its popular use of the plant. Elsevier 2019-11-09 /pmc/articles/PMC6861650/ /pubmed/31763182 http://dx.doi.org/10.1016/j.toxrep.2019.10.018 Text en © 2019 Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
de Araújo Rodrigues, Patrícia
de Morais, Selene Maia
Aguiar, Liza Araújo
Vila-Nova, Nadja Soares
Benjamin, Stephen Rathinaraj
Effect of Byrsonima sericea DC. leaf extracts on mice gastrointestinal tract
title Effect of Byrsonima sericea DC. leaf extracts on mice gastrointestinal tract
title_full Effect of Byrsonima sericea DC. leaf extracts on mice gastrointestinal tract
title_fullStr Effect of Byrsonima sericea DC. leaf extracts on mice gastrointestinal tract
title_full_unstemmed Effect of Byrsonima sericea DC. leaf extracts on mice gastrointestinal tract
title_short Effect of Byrsonima sericea DC. leaf extracts on mice gastrointestinal tract
title_sort effect of byrsonima sericea dc. leaf extracts on mice gastrointestinal tract
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861650/
https://www.ncbi.nlm.nih.gov/pubmed/31763182
http://dx.doi.org/10.1016/j.toxrep.2019.10.018
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