The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B

Due to the increasing number of Candida albicans’ infections and the resistance of this pathogenic fungus to drugs, new therapeutic strategies are sought. One of such strategies may be the use of static magnetic field (SMF). C. albicans cultures were subjected to static magnetic field of the inducti...

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Autores principales: Sztafrowski, Dariusz, Suchodolski, Jakub, Muraszko, Jakub, Sigler, Karel, Krasowska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861703/
https://www.ncbi.nlm.nih.gov/pubmed/30788802
http://dx.doi.org/10.1007/s12223-019-00686-3
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author Sztafrowski, Dariusz
Suchodolski, Jakub
Muraszko, Jakub
Sigler, Karel
Krasowska, Anna
author_facet Sztafrowski, Dariusz
Suchodolski, Jakub
Muraszko, Jakub
Sigler, Karel
Krasowska, Anna
author_sort Sztafrowski, Dariusz
collection PubMed
description Due to the increasing number of Candida albicans’ infections and the resistance of this pathogenic fungus to drugs, new therapeutic strategies are sought. One of such strategies may be the use of static magnetic field (SMF). C. albicans cultures were subjected to static magnetic field of the induction 0.5 T in the presence of fluconazole and amphotericin B. We identified a reduction of C. albicans hyphal length. Also, a statistically significant additional effect on the viability of C. albicans was revealed when SMF was combined with the antimycotic drug amphotericin B. The synergistic effect of this antimycotic and SMF may be due to the fact that amphotericin B binds to ergosterol in plasma membrane and SMF similarly to MF could influence domain orientation in plasma membrane (PM).
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spelling pubmed-68617032019-12-03 The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B Sztafrowski, Dariusz Suchodolski, Jakub Muraszko, Jakub Sigler, Karel Krasowska, Anna Folia Microbiol (Praha) Original Article Due to the increasing number of Candida albicans’ infections and the resistance of this pathogenic fungus to drugs, new therapeutic strategies are sought. One of such strategies may be the use of static magnetic field (SMF). C. albicans cultures were subjected to static magnetic field of the induction 0.5 T in the presence of fluconazole and amphotericin B. We identified a reduction of C. albicans hyphal length. Also, a statistically significant additional effect on the viability of C. albicans was revealed when SMF was combined with the antimycotic drug amphotericin B. The synergistic effect of this antimycotic and SMF may be due to the fact that amphotericin B binds to ergosterol in plasma membrane and SMF similarly to MF could influence domain orientation in plasma membrane (PM). Springer Netherlands 2019-02-20 2019 /pmc/articles/PMC6861703/ /pubmed/30788802 http://dx.doi.org/10.1007/s12223-019-00686-3 Text en © The Author(s) 2019 OpenAccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Sztafrowski, Dariusz
Suchodolski, Jakub
Muraszko, Jakub
Sigler, Karel
Krasowska, Anna
The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B
title The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B
title_full The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B
title_fullStr The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B
title_full_unstemmed The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B
title_short The influence of N and S poles of static magnetic field (SMF) on Candida albicans hyphal formation and antifungal activity of amphotericin B
title_sort influence of n and s poles of static magnetic field (smf) on candida albicans hyphal formation and antifungal activity of amphotericin b
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861703/
https://www.ncbi.nlm.nih.gov/pubmed/30788802
http://dx.doi.org/10.1007/s12223-019-00686-3
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