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The Landscape of Actionable Gene Fusions in Colorectal Cancer

The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched with new chemotherapy combinations and biological agents that lead to a remarkable improvement in patients’ outcome. Kinase gene fusions account for less than 1% of mCRC overall but are enriched in patients with...

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Autores principales: Pagani, Filippo, Randon, Giovanni, Guarini, Vincenzo, Raimondi, Alessandra, Prisciandaro, Michele, Lobefaro, Riccardo, Di Bartolomeo, Maria, Sozzi, Gabriella, de Braud, Filippo, Gasparini, Patrizia, Pietrantonio, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861915/
https://www.ncbi.nlm.nih.gov/pubmed/31731495
http://dx.doi.org/10.3390/ijms20215319
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author Pagani, Filippo
Randon, Giovanni
Guarini, Vincenzo
Raimondi, Alessandra
Prisciandaro, Michele
Lobefaro, Riccardo
Di Bartolomeo, Maria
Sozzi, Gabriella
de Braud, Filippo
Gasparini, Patrizia
Pietrantonio, Filippo
author_facet Pagani, Filippo
Randon, Giovanni
Guarini, Vincenzo
Raimondi, Alessandra
Prisciandaro, Michele
Lobefaro, Riccardo
Di Bartolomeo, Maria
Sozzi, Gabriella
de Braud, Filippo
Gasparini, Patrizia
Pietrantonio, Filippo
author_sort Pagani, Filippo
collection PubMed
description The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched with new chemotherapy combinations and biological agents that lead to a remarkable improvement in patients’ outcome. Kinase gene fusions account for less than 1% of mCRC overall but are enriched in patients with high microsatellite instability, RAS/BRAF wild-type colorectal cancer. mCRC patients harboring such alterations show a poor prognosis with standard treatments that could be reversed by adopting novel therapeutic strategies. Moving forward to a positive selection of mCRC patients suitable for targeted therapy in the era of personalized medicine, actionable gene fusions, although rare, represent a peculiar opportunity to disrupt a tumor alteration to achieve therapeutic goal. Here we summarize the current knowledge on potentially actionable gene fusions in colorectal cancer available from retrospective experiences and promising preliminary results of new basket trials.
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spelling pubmed-68619152019-12-05 The Landscape of Actionable Gene Fusions in Colorectal Cancer Pagani, Filippo Randon, Giovanni Guarini, Vincenzo Raimondi, Alessandra Prisciandaro, Michele Lobefaro, Riccardo Di Bartolomeo, Maria Sozzi, Gabriella de Braud, Filippo Gasparini, Patrizia Pietrantonio, Filippo Int J Mol Sci Review The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched with new chemotherapy combinations and biological agents that lead to a remarkable improvement in patients’ outcome. Kinase gene fusions account for less than 1% of mCRC overall but are enriched in patients with high microsatellite instability, RAS/BRAF wild-type colorectal cancer. mCRC patients harboring such alterations show a poor prognosis with standard treatments that could be reversed by adopting novel therapeutic strategies. Moving forward to a positive selection of mCRC patients suitable for targeted therapy in the era of personalized medicine, actionable gene fusions, although rare, represent a peculiar opportunity to disrupt a tumor alteration to achieve therapeutic goal. Here we summarize the current knowledge on potentially actionable gene fusions in colorectal cancer available from retrospective experiences and promising preliminary results of new basket trials. MDPI 2019-10-25 /pmc/articles/PMC6861915/ /pubmed/31731495 http://dx.doi.org/10.3390/ijms20215319 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pagani, Filippo
Randon, Giovanni
Guarini, Vincenzo
Raimondi, Alessandra
Prisciandaro, Michele
Lobefaro, Riccardo
Di Bartolomeo, Maria
Sozzi, Gabriella
de Braud, Filippo
Gasparini, Patrizia
Pietrantonio, Filippo
The Landscape of Actionable Gene Fusions in Colorectal Cancer
title The Landscape of Actionable Gene Fusions in Colorectal Cancer
title_full The Landscape of Actionable Gene Fusions in Colorectal Cancer
title_fullStr The Landscape of Actionable Gene Fusions in Colorectal Cancer
title_full_unstemmed The Landscape of Actionable Gene Fusions in Colorectal Cancer
title_short The Landscape of Actionable Gene Fusions in Colorectal Cancer
title_sort landscape of actionable gene fusions in colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861915/
https://www.ncbi.nlm.nih.gov/pubmed/31731495
http://dx.doi.org/10.3390/ijms20215319
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