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The Landscape of Actionable Gene Fusions in Colorectal Cancer
The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched with new chemotherapy combinations and biological agents that lead to a remarkable improvement in patients’ outcome. Kinase gene fusions account for less than 1% of mCRC overall but are enriched in patients with...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861915/ https://www.ncbi.nlm.nih.gov/pubmed/31731495 http://dx.doi.org/10.3390/ijms20215319 |
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author | Pagani, Filippo Randon, Giovanni Guarini, Vincenzo Raimondi, Alessandra Prisciandaro, Michele Lobefaro, Riccardo Di Bartolomeo, Maria Sozzi, Gabriella de Braud, Filippo Gasparini, Patrizia Pietrantonio, Filippo |
author_facet | Pagani, Filippo Randon, Giovanni Guarini, Vincenzo Raimondi, Alessandra Prisciandaro, Michele Lobefaro, Riccardo Di Bartolomeo, Maria Sozzi, Gabriella de Braud, Filippo Gasparini, Patrizia Pietrantonio, Filippo |
author_sort | Pagani, Filippo |
collection | PubMed |
description | The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched with new chemotherapy combinations and biological agents that lead to a remarkable improvement in patients’ outcome. Kinase gene fusions account for less than 1% of mCRC overall but are enriched in patients with high microsatellite instability, RAS/BRAF wild-type colorectal cancer. mCRC patients harboring such alterations show a poor prognosis with standard treatments that could be reversed by adopting novel therapeutic strategies. Moving forward to a positive selection of mCRC patients suitable for targeted therapy in the era of personalized medicine, actionable gene fusions, although rare, represent a peculiar opportunity to disrupt a tumor alteration to achieve therapeutic goal. Here we summarize the current knowledge on potentially actionable gene fusions in colorectal cancer available from retrospective experiences and promising preliminary results of new basket trials. |
format | Online Article Text |
id | pubmed-6861915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-68619152019-12-05 The Landscape of Actionable Gene Fusions in Colorectal Cancer Pagani, Filippo Randon, Giovanni Guarini, Vincenzo Raimondi, Alessandra Prisciandaro, Michele Lobefaro, Riccardo Di Bartolomeo, Maria Sozzi, Gabriella de Braud, Filippo Gasparini, Patrizia Pietrantonio, Filippo Int J Mol Sci Review The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched with new chemotherapy combinations and biological agents that lead to a remarkable improvement in patients’ outcome. Kinase gene fusions account for less than 1% of mCRC overall but are enriched in patients with high microsatellite instability, RAS/BRAF wild-type colorectal cancer. mCRC patients harboring such alterations show a poor prognosis with standard treatments that could be reversed by adopting novel therapeutic strategies. Moving forward to a positive selection of mCRC patients suitable for targeted therapy in the era of personalized medicine, actionable gene fusions, although rare, represent a peculiar opportunity to disrupt a tumor alteration to achieve therapeutic goal. Here we summarize the current knowledge on potentially actionable gene fusions in colorectal cancer available from retrospective experiences and promising preliminary results of new basket trials. MDPI 2019-10-25 /pmc/articles/PMC6861915/ /pubmed/31731495 http://dx.doi.org/10.3390/ijms20215319 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pagani, Filippo Randon, Giovanni Guarini, Vincenzo Raimondi, Alessandra Prisciandaro, Michele Lobefaro, Riccardo Di Bartolomeo, Maria Sozzi, Gabriella de Braud, Filippo Gasparini, Patrizia Pietrantonio, Filippo The Landscape of Actionable Gene Fusions in Colorectal Cancer |
title | The Landscape of Actionable Gene Fusions in Colorectal Cancer |
title_full | The Landscape of Actionable Gene Fusions in Colorectal Cancer |
title_fullStr | The Landscape of Actionable Gene Fusions in Colorectal Cancer |
title_full_unstemmed | The Landscape of Actionable Gene Fusions in Colorectal Cancer |
title_short | The Landscape of Actionable Gene Fusions in Colorectal Cancer |
title_sort | landscape of actionable gene fusions in colorectal cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861915/ https://www.ncbi.nlm.nih.gov/pubmed/31731495 http://dx.doi.org/10.3390/ijms20215319 |
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