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Evidence for Nanoparticle-Induced Lysosomal Dysfunction in Lung Adenocarcinoma (A549) Cells

Background: Polystyrene nanoparticles (PNP) are taken up by primary rat alveolar epithelial cell monolayers (RAECM) in a time-, dose-, and size-dependent manner without involving endocytosis. Internalized PNP in RAECM activate autophagy, are delivered to lysosomes, and undergo [Ca(2+)]-dependent exo...

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Detalles Bibliográficos
Autores principales:	Sipos, Arnold, Kim, Kwang-Jin, Sioutas, Constantinos, Crandall, Edward D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861930/ https://www.ncbi.nlm.nih.gov/pubmed/31652767 http://dx.doi.org/10.3390/ijms20215253

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